Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

ABSTRACT Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior...

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Bibliographic Details
Main Authors: Eili Y. Klein, Deena Blumenkrantz, Adrian Serohijos, Eugene Shakhnovich, Jeong-Mo Choi, João V. Rodrigues, Brendan D. Smith, Andrew P. Lane, Andrew Feldman, Andrew Pekosz
Format: Article
Language:English
Published: American Society for Microbiology 2018-02-01
Series:mSphere
Subjects:
evolution
hemagglutinin
influenza
protein stability
Online Access:https://journals.asm.org/doi/10.1128/mSphereDirect.00554-17

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