Reactive oxygen species-responsive HET0016 prodrug-loaded liposomes attenuate neuroinflammation and improve neurological deficit in a rat model of juvenile traumatic brain injury

Reactive oxygen species-responsive HET0016 prodrug-loaded liposomes attenuate neuroinflammation and improve neurological deficit in a rat model of juvenile traumatic brain injury

The arachidonic acid pathway metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to ischemia/reperfusion brain injury. Inhibition of 20-HETE formation can protect the developing brain from global ischemia. In previous studies, we have found that treatment with the 20-HETE synthesis inhi...

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Bibliographic Details
Main Authors: Jun Qin, Xiaoli Chen, Rui Wang, Zedan Tian, Yang Li, Shiyu Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neuroscience
Subjects:
traumatic brain injury
HET0016
neuroinflammation
reactive oxygen species responsive
liposomes
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1153349/full

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