Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain
Urokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of plasminogen activation system, a proteolytic system involved in many physiological and patological processes. In this paper their induction by etoposide, a topoisomerase II inhibitor, in A1235 glioblastoma cell strain is...
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| Format: | Article |
| Language: | English |
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University of Zagreb Faculty of Food Technology and Biotechnology
2002-01-01
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| Series: | Food Technology and Biotechnology |
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| Online Access: | http://hrcak.srce.hr/file/262924 |
| _version_ | 1827611572554432512 |
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| author | Branko Brdar Maja Matulić |
| author_facet | Branko Brdar Maja Matulić |
| author_sort | Branko Brdar |
| collection | DOAJ |
| description | Urokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of plasminogen activation system, a proteolytic system involved in many physiological and patological processes. In this paper their induction by etoposide, a topoisomerase II inhibitor, in A1235 glioblastoma cell strain is described. Etoposide induced uPA and PAI production, in a dose- and time-dependent manner. Induction was based on the activation of their promoters and extracellular proteolysis was dependent on their equilibrium. Etoposide caused p53 activation and p21 and gadd45 induction, which could be responsible for the cell growth arrest. Our data indicate that several pathways could be involved in the uPA and PAI induction. |
| first_indexed | 2024-03-09T08:09:00Z |
| format | Article |
| id | doaj.art-ccffb6b5b0a649e28cf7a6285562be0d |
| institution | Directory Open Access Journal |
| issn | 1330-9862 1334-2606 |
| language | English |
| last_indexed | 2024-03-09T08:09:00Z |
| publishDate | 2002-01-01 |
| publisher | University of Zagreb Faculty of Food Technology and Biotechnology |
| record_format | Article |
| series | Food Technology and Biotechnology |
| spelling | doaj.art-ccffb6b5b0a649e28cf7a6285562be0d2023-12-02T23:39:27ZengUniversity of Zagreb Faculty of Food Technology and BiotechnologyFood Technology and Biotechnology1330-98621334-26062002-01-0140117Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell StrainBranko Brdar0Maja Matulić1Rudjer Bošković Institute, Department of Molecular Genetics, HR-10000 Zagreb, CroatiaRudjer Bošković Institute, Department of Molecular Genetics, HR-10000 Zagreb, CroatiaUrokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of plasminogen activation system, a proteolytic system involved in many physiological and patological processes. In this paper their induction by etoposide, a topoisomerase II inhibitor, in A1235 glioblastoma cell strain is described. Etoposide induced uPA and PAI production, in a dose- and time-dependent manner. Induction was based on the activation of their promoters and extracellular proteolysis was dependent on their equilibrium. Etoposide caused p53 activation and p21 and gadd45 induction, which could be responsible for the cell growth arrest. Our data indicate that several pathways could be involved in the uPA and PAI induction.http://hrcak.srce.hr/file/262924urokinaseplasminogen activator inhibitoruPA promoterPAI promoteretoposideglioblastoma cell strain |
| spellingShingle | Branko Brdar Maja Matulić Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain Food Technology and Biotechnology urokinase plasminogen activator inhibitor uPA promoter PAI promoter etoposide glioblastoma cell strain |
| title | Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain |
| title_full | Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain |
| title_fullStr | Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain |
| title_full_unstemmed | Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain |
| title_short | Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain |
| title_sort | urokinase type plasminogen activator and plasminogen activator inhibitor induction by etoposide in a glioblastoma cell strain |
| topic | urokinase plasminogen activator inhibitor uPA promoter PAI promoter etoposide glioblastoma cell strain |
| url | http://hrcak.srce.hr/file/262924 |
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