Enhanced protein translocation to mammalian cells by expression of EtgA transglycosylase in a synthetic injector E. coli strain

Enhanced protein translocation to mammalian cells by expression of EtgA transglycosylase in a synthetic injector E. coli strain

Abstract Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells. The use of injectisomes for delivery of therapeutic proteins in...

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Bibliographic Details
Main Authors: Beatriz Álvarez, Víctor Muñoz-Abad, Alejandro Asensio-Calavia, Luis Ángel Fernández
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Microbial Cell Factories
Subjects:
E. coli
Type III secretion systems
Injectisomes
EtgA
SIEC
Peptidoglycan
Online Access:https://doi.org/10.1186/s12934-022-01860-y

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