External jugular veinous thrombosis: A rare presentation of Hansen's disease
Veinous thrombosis is a rare manifestation of leprosy (Hansen's disease). In this case report, we bring to notice this extremely rare presentation and challenges faced during management. A 26-year-old young healthy individual presented with painless cord-like swellings on both sides of the neck...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Vascular and Endovascular Surgery |
| Subjects: | |
| Online Access: | http://www.indjvascsurg.org/article.asp?issn=0972-0820;year=2023;volume=10;issue=3;spage=219;epage=221;aulast=Chaudhuri |
| _version_ | 1827309241390596096 |
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| author | Deep Jyoti Chaudhuri Pranati Swain Vipin Venugopal Nair Biju Vasudevan Yugan Prakash Yadav |
| author_facet | Deep Jyoti Chaudhuri Pranati Swain Vipin Venugopal Nair Biju Vasudevan Yugan Prakash Yadav |
| author_sort | Deep Jyoti Chaudhuri |
| collection | DOAJ |
| description | Veinous thrombosis is a rare manifestation of leprosy (Hansen's disease). In this case report, we bring to notice this extremely rare presentation and challenges faced during management. A 26-year-old young healthy individual presented with painless cord-like swellings on both sides of the neck for 1 month. This was evaluated to be external jugular vein (EJV) thrombosis on ultrasonography Doppler. Trying to evaluate the cause of the thrombosis, there was no specific etiology found. On further detailed evaluation, it was found that he had hypopigmented skin patches. This led to the diagnosis of borderline tuberculoid leprosy downgrading to borderline lepromatous in type 1 lepra reaction. He responded to rifampicin, clofazimine, and dapsone with progressive resolution of skin lesions. Simultaneous treatment with apixaban caused complete resolution of EJV thrombosis. Further evaluation revealed heterozygous methylenetetrahydrofolate reductase mutation and beta-2-glycoprotein immunoglobulin M positivity. An extensive literature review suggested that intimal damage caused by lepra bacilli can lead to veinous thrombosis in Hansen's disease. However, the interplay of genetic procoagulant predispositions in phenotypic presentation is yet to be determined. |
| first_indexed | 2024-04-24T19:27:00Z |
| format | Article |
| id | doaj.art-cd0409625f704bfe9b964f39df0722d1 |
| institution | Directory Open Access Journal |
| issn | 0972-0820 2394-0999 |
| language | English |
| last_indexed | 2024-04-24T19:27:00Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Vascular and Endovascular Surgery |
| spelling | doaj.art-cd0409625f704bfe9b964f39df0722d12024-03-25T14:45:23ZengWolters Kluwer Medknow PublicationsIndian Journal of Vascular and Endovascular Surgery0972-08202394-09992023-01-0110321922110.4103/ijves.ijves_13_23External jugular veinous thrombosis: A rare presentation of Hansen's diseaseDeep Jyoti ChaudhuriPranati SwainVipin Venugopal NairBiju VasudevanYugan Prakash YadavVeinous thrombosis is a rare manifestation of leprosy (Hansen's disease). In this case report, we bring to notice this extremely rare presentation and challenges faced during management. A 26-year-old young healthy individual presented with painless cord-like swellings on both sides of the neck for 1 month. This was evaluated to be external jugular vein (EJV) thrombosis on ultrasonography Doppler. Trying to evaluate the cause of the thrombosis, there was no specific etiology found. On further detailed evaluation, it was found that he had hypopigmented skin patches. This led to the diagnosis of borderline tuberculoid leprosy downgrading to borderline lepromatous in type 1 lepra reaction. He responded to rifampicin, clofazimine, and dapsone with progressive resolution of skin lesions. Simultaneous treatment with apixaban caused complete resolution of EJV thrombosis. Further evaluation revealed heterozygous methylenetetrahydrofolate reductase mutation and beta-2-glycoprotein immunoglobulin M positivity. An extensive literature review suggested that intimal damage caused by lepra bacilli can lead to veinous thrombosis in Hansen's disease. However, the interplay of genetic procoagulant predispositions in phenotypic presentation is yet to be determined.http://www.indjvascsurg.org/article.asp?issn=0972-0820;year=2023;volume=10;issue=3;spage=219;epage=221;aulast=Chaudhuriborderline lepromatousborderline tuberculoidexternal jugular vein thrombosishansen's disease |
| spellingShingle | Deep Jyoti Chaudhuri Pranati Swain Vipin Venugopal Nair Biju Vasudevan Yugan Prakash Yadav External jugular veinous thrombosis: A rare presentation of Hansen's disease Indian Journal of Vascular and Endovascular Surgery borderline lepromatous borderline tuberculoid external jugular vein thrombosis hansen's disease |
| title | External jugular veinous thrombosis: A rare presentation of Hansen's disease |
| title_full | External jugular veinous thrombosis: A rare presentation of Hansen's disease |
| title_fullStr | External jugular veinous thrombosis: A rare presentation of Hansen's disease |
| title_full_unstemmed | External jugular veinous thrombosis: A rare presentation of Hansen's disease |
| title_short | External jugular veinous thrombosis: A rare presentation of Hansen's disease |
| title_sort | external jugular veinous thrombosis a rare presentation of hansen s disease |
| topic | borderline lepromatous borderline tuberculoid external jugular vein thrombosis hansen's disease |
| url | http://www.indjvascsurg.org/article.asp?issn=0972-0820;year=2023;volume=10;issue=3;spage=219;epage=221;aulast=Chaudhuri |
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