Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study
Abstract Background and Objective To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods A randomized controlled study was conducted involving 60 GERC patients who were divided into the intervention group...
| Hlavní autoři: | , , , , , , , , , , , , |
|---|---|
| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
BMC
2024-04-01
|
| Edice: | Respiratory Research |
| Témata: | |
| On-line přístup: | https://doi.org/10.1186/s12931-024-02783-5 |
| _version_ | 1827276991517163520 |
|---|---|
| author | Shanshan Niu Tongyangzi Zhang Wanzhen Li Siwan Wen Lei Dong Shengyuan Wang Wenbo Shi Cuiqin Shi Yuqin Shen Qianchun Huang Yaling Tan Xianghuai Xu Li Yu |
| author_facet | Shanshan Niu Tongyangzi Zhang Wanzhen Li Siwan Wen Lei Dong Shengyuan Wang Wenbo Shi Cuiqin Shi Yuqin Shen Qianchun Huang Yaling Tan Xianghuai Xu Li Yu |
| author_sort | Shanshan Niu |
| collection | DOAJ |
| description | Abstract Background and Objective To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods A randomized controlled study was conducted involving 60 GERC patients who were divided into the intervention group and the control group (each with 30 patients). Both groups received routine medication treatment for GERC, while the intervention group received DEP training additionally. Both groups were evaluated by cough symptom scores, Hull airway reflux questionnaire (HARQ), gastroesophageal reflux diagnostic questionnaire (GerdQ), generalized anxiety disorder scale-7 (GAD-7), patient health questionnaire-9 (PHQ-9), Pittsburgh sleep quality index (PSQI), the Leicester cough questionnaire (LCQ), as well as capsaicin cough sensitivity testing, B-ultrasound and surface electromyography (sEMG) of the diaphragmatic muscles before and after treatment. The cough resolution rate and changes of the above indictors was compared between the two groups after eight weeks of treatment. Results After eight weeks of treatment, cough symptoms improved in both groups, but the cough resolution rate in the intervention group of 94% was significantly higher than that in the control group of 77% (χ2 = 6.402, P = 0.041). The intervention group showed significant improvements to the control group in GerdQ (6.13(0.35) VS 6.57(0.77)), GAD-7 (0(0;1) VS 1(0;3)), PSQI (2(1;3) VS 4(3;6)), LCQ (17.19(1.56) VS 15.88(1.92)) and PHQ-9 (0(0;0) VS 0(0;3)) after treatment. Compared to control group, sEMG activity of the diaphragmatic muscle was significantly increased in the intervention group after treatment, measured during DEP (79.00(2.49) VS 74.65 (1.93)) and quiet breathing (72.73 (1.96) VS 67.15 (2.48)). Conclusion DEP training can improve cough symptoms as an adjunctive treatment in GERC patients. Trial registration The protocol was registered in February 2, 2022 via the Chinese Clinical Trials Register ( http://www.chictr.org.cn/ ) [ChiCTR2200056246]. |
| first_indexed | 2024-04-24T07:13:24Z |
| format | Article |
| id | doaj.art-cd07439c2a7f45ec90e7fce1dccb2a4d |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-24T07:13:24Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-cd07439c2a7f45ec90e7fce1dccb2a4d2024-04-21T11:27:56ZengBMCRespiratory Research1465-993X2024-04-0125111310.1186/s12931-024-02783-5Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled studyShanshan Niu0Tongyangzi Zhang1Wanzhen Li2Siwan Wen3Lei Dong4Shengyuan Wang5Wenbo Shi6Cuiqin Shi7Yuqin Shen8Qianchun Huang9Yaling Tan10Xianghuai Xu11Li Yu12Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Cardiac Rehabilitation, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Cardiac Rehabilitation, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityAbstract Background and Objective To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods A randomized controlled study was conducted involving 60 GERC patients who were divided into the intervention group and the control group (each with 30 patients). Both groups received routine medication treatment for GERC, while the intervention group received DEP training additionally. Both groups were evaluated by cough symptom scores, Hull airway reflux questionnaire (HARQ), gastroesophageal reflux diagnostic questionnaire (GerdQ), generalized anxiety disorder scale-7 (GAD-7), patient health questionnaire-9 (PHQ-9), Pittsburgh sleep quality index (PSQI), the Leicester cough questionnaire (LCQ), as well as capsaicin cough sensitivity testing, B-ultrasound and surface electromyography (sEMG) of the diaphragmatic muscles before and after treatment. The cough resolution rate and changes of the above indictors was compared between the two groups after eight weeks of treatment. Results After eight weeks of treatment, cough symptoms improved in both groups, but the cough resolution rate in the intervention group of 94% was significantly higher than that in the control group of 77% (χ2 = 6.402, P = 0.041). The intervention group showed significant improvements to the control group in GerdQ (6.13(0.35) VS 6.57(0.77)), GAD-7 (0(0;1) VS 1(0;3)), PSQI (2(1;3) VS 4(3;6)), LCQ (17.19(1.56) VS 15.88(1.92)) and PHQ-9 (0(0;0) VS 0(0;3)) after treatment. Compared to control group, sEMG activity of the diaphragmatic muscle was significantly increased in the intervention group after treatment, measured during DEP (79.00(2.49) VS 74.65 (1.93)) and quiet breathing (72.73 (1.96) VS 67.15 (2.48)). Conclusion DEP training can improve cough symptoms as an adjunctive treatment in GERC patients. Trial registration The protocol was registered in February 2, 2022 via the Chinese Clinical Trials Register ( http://www.chictr.org.cn/ ) [ChiCTR2200056246].https://doi.org/10.1186/s12931-024-02783-5Deep diaphragmatic breathing trainingChronic coughGastroesophageal refluxDiaphragmNon-pharmacological treatment |
| spellingShingle | Shanshan Niu Tongyangzi Zhang Wanzhen Li Siwan Wen Lei Dong Shengyuan Wang Wenbo Shi Cuiqin Shi Yuqin Shen Qianchun Huang Yaling Tan Xianghuai Xu Li Yu Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study Respiratory Research Deep diaphragmatic breathing training Chronic cough Gastroesophageal reflux Diaphragm Non-pharmacological treatment |
| title | Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study |
| title_full | Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study |
| title_fullStr | Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study |
| title_full_unstemmed | Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study |
| title_short | Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study |
| title_sort | positive effect of deep diaphragmatic breathing training on gastroesophageal reflux induced chronic cough a clinical randomized controlled study |
| topic | Deep diaphragmatic breathing training Chronic cough Gastroesophageal reflux Diaphragm Non-pharmacological treatment |
| url | https://doi.org/10.1186/s12931-024-02783-5 |
| work_keys_str_mv | AT shanshanniu positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT tongyangzizhang positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT wanzhenli positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT siwanwen positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT leidong positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT shengyuanwang positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT wenboshi positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT cuiqinshi positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT yuqinshen positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT qianchunhuang positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT yalingtan positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT xianghuaixu positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy AT liyu positiveeffectofdeepdiaphragmaticbreathingtrainingongastroesophagealrefluxinducedchroniccoughaclinicalrandomizedcontrolledstudy |