Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an antigen-presenting cell (APC) to discriminate foreign from self antigens and initiate adaptive immune responses. In addition, T cell activation generally requires binding of this same pMHC to a CD4 or CD8 co-receptor,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00206/full |
| _version_ | 1819292815699476480 |
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| author | Yili eLi Roy eMariuzza |
| author_facet | Yili eLi Roy eMariuzza |
| author_sort | Yili eLi |
| collection | DOAJ |
| description | T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an antigen-presenting cell (APC) to discriminate foreign from self antigens and initiate adaptive immune responses. In addition, T cell activation generally requires binding of this same pMHC to a CD4 or CD8 co-receptor, resulting in assembly of a TCR–pMHC–CD4 or TCR–pMHC–CD8 complex and recruitment of Lck via its association with the co-receptor. Here we review structural and biophysical studies of CD4 and CD8 interactions with MHC molecules and TCR–pMHC complexes. Crystal structures have been determined of CD8alpha/alpha and CD8alpha/beta in complex with MHC class I, of CD4 bound to MHC class II, and of a complete TCR–pMHC–CD4 ternary complex. Additionally, the binding of these co-receptors to pMHC and TCR–pMHC ligands has been investigated both in solution and in situ at the T cell–APC interface. Together, these studies have provided key insights into the role of CD4 and CD8 in T cell activation, and into how these co-receptors focus TCR on MHC to guide TCR docking on pMHC during thymic T cell selection. |
| first_indexed | 2024-12-24T04:00:32Z |
| format | Article |
| id | doaj.art-cd0b3e2302ab4961a6ac218f8d857c55 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T04:00:32Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cd0b3e2302ab4961a6ac218f8d857c552022-12-21T17:16:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-07-01410.3389/fimmu.2013.0020655589Structural and biophysical insights into the role of CD4 and CD8 in T cell activationYili eLi0Roy eMariuzza1University of MarylandUniversity of MarylandT cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an antigen-presenting cell (APC) to discriminate foreign from self antigens and initiate adaptive immune responses. In addition, T cell activation generally requires binding of this same pMHC to a CD4 or CD8 co-receptor, resulting in assembly of a TCR–pMHC–CD4 or TCR–pMHC–CD8 complex and recruitment of Lck via its association with the co-receptor. Here we review structural and biophysical studies of CD4 and CD8 interactions with MHC molecules and TCR–pMHC complexes. Crystal structures have been determined of CD8alpha/alpha and CD8alpha/beta in complex with MHC class I, of CD4 bound to MHC class II, and of a complete TCR–pMHC–CD4 ternary complex. Additionally, the binding of these co-receptors to pMHC and TCR–pMHC ligands has been investigated both in solution and in situ at the T cell–APC interface. Together, these studies have provided key insights into the role of CD4 and CD8 in T cell activation, and into how these co-receptors focus TCR on MHC to guide TCR docking on pMHC during thymic T cell selection.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00206/fullStructureT cell receptorCD4MHCT cell activationCD8 |
| spellingShingle | Yili eLi Roy eMariuzza Structural and biophysical insights into the role of CD4 and CD8 in T cell activation Frontiers in Immunology Structure T cell receptor CD4 MHC T cell activation CD8 |
| title | Structural and biophysical insights into the role of CD4 and CD8 in T cell activation |
| title_full | Structural and biophysical insights into the role of CD4 and CD8 in T cell activation |
| title_fullStr | Structural and biophysical insights into the role of CD4 and CD8 in T cell activation |
| title_full_unstemmed | Structural and biophysical insights into the role of CD4 and CD8 in T cell activation |
| title_short | Structural and biophysical insights into the role of CD4 and CD8 in T cell activation |
| title_sort | structural and biophysical insights into the role of cd4 and cd8 in t cell activation |
| topic | Structure T cell receptor CD4 MHC T cell activation CD8 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00206/full |
| work_keys_str_mv | AT yilieli structuralandbiophysicalinsightsintotheroleofcd4andcd8intcellactivation AT royemariuzza structuralandbiophysicalinsightsintotheroleofcd4andcd8intcellactivation |