Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis
Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. Propose: To determine the serum level of interleukin-18 (IL-1...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=474;epage=476;aulast=Jahanbani-Ardakani |
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| author | Hamidreza Jahanbani-Ardakani Fereshteh Alsahebfosoul Masoud Etemadifar Seyed-Hossein Abtahi |
| author_facet | Hamidreza Jahanbani-Ardakani Fereshteh Alsahebfosoul Masoud Etemadifar Seyed-Hossein Abtahi |
| author_sort | Hamidreza Jahanbani-Ardakani |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. Propose: To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518, rs360719, and rs187238). Methods: In this case–control study, 110 MS patients diagnosed according to the McDonald criteria and 110 healthy individuals were recruited. IL-18 gene polymorphisms were genotyped by polymerase chain reaction high-resolution melt test, and IL-18 serum level was determined by enzyme-linked immunosorbent assay technique. Results: The mean age of the MS patients (89 females and 21 males) and the control group (89 females and 21 males) was 30.3 ± 9.25 and 30.28 ± 9.13 years, respectively. The mean serum levels of IL-18 in MS patients and healthy individuals were 341.56 ± 39.22 Pg/Ml and 146.52 ± 29.30 Pg/Ml, respectively (P < 0.001). The genotype of rs1946518 (but not rs360719 and rs187238) was significantly different between groups (P = 0.037 and P = 0.069, respectively). Conclusion: In this study, we showed the significant higher IL-18 serum level and significant different frequencies of two polymorphisms of IL-18 in MS patients. These results show the important roles of IL-18 in MS pathogenesis. However, more studies are needed to verify our results in larger sample size. |
| first_indexed | 2024-12-22T06:58:24Z |
| format | Article |
| id | doaj.art-cd0cc732d81a4bcabc38c11b944777a8 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-22T06:58:24Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-cd0cc732d81a4bcabc38c11b944777a82022-12-21T18:34:52ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492019-01-0122447447610.4103/aian.AIAN_515_18Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosisHamidreza Jahanbani-ArdakaniFereshteh AlsahebfosoulMasoud EtemadifarSeyed-Hossein AbtahiBackground: Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. Propose: To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518, rs360719, and rs187238). Methods: In this case–control study, 110 MS patients diagnosed according to the McDonald criteria and 110 healthy individuals were recruited. IL-18 gene polymorphisms were genotyped by polymerase chain reaction high-resolution melt test, and IL-18 serum level was determined by enzyme-linked immunosorbent assay technique. Results: The mean age of the MS patients (89 females and 21 males) and the control group (89 females and 21 males) was 30.3 ± 9.25 and 30.28 ± 9.13 years, respectively. The mean serum levels of IL-18 in MS patients and healthy individuals were 341.56 ± 39.22 Pg/Ml and 146.52 ± 29.30 Pg/Ml, respectively (P < 0.001). The genotype of rs1946518 (but not rs360719 and rs187238) was significantly different between groups (P = 0.037 and P = 0.069, respectively). Conclusion: In this study, we showed the significant higher IL-18 serum level and significant different frequencies of two polymorphisms of IL-18 in MS patients. These results show the important roles of IL-18 in MS pathogenesis. However, more studies are needed to verify our results in larger sample size.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=474;epage=476;aulast=Jahanbani-Ardakanimultiple sclerosisinterleukin 18serum levelsingle-nucleotide polymorphism |
| spellingShingle | Hamidreza Jahanbani-Ardakani Fereshteh Alsahebfosoul Masoud Etemadifar Seyed-Hossein Abtahi Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis Annals of Indian Academy of Neurology multiple sclerosis interleukin 18 serum level single-nucleotide polymorphism |
| title | Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| title_full | Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| title_fullStr | Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| title_full_unstemmed | Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| title_short | Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| title_sort | interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis |
| topic | multiple sclerosis interleukin 18 serum level single-nucleotide polymorphism |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=474;epage=476;aulast=Jahanbani-Ardakani |
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