Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers
Background and Aim: Infectious bursal disease (IBD) or Gumboro disease is one of the most detrimental diseases in the poultry industry worldwide. Previous scientific studies have shown that live IBD vaccination might induce transient immunosuppression, leading to suboptimal vaccine responses, and th...
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| Format: | Article |
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Veterinary World
2021-01-01
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| Series: | Veterinary World |
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| Online Access: | http://www.veterinaryworld.org/Vol.14/January-2021/9.pdf |
| _version_ | 1819111184095248384 |
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| author | Thotsapol Thomrongsuwannakij Nataya Charoenvisal Niwat Chansiripornchai |
| author_facet | Thotsapol Thomrongsuwannakij Nataya Charoenvisal Niwat Chansiripornchai |
| author_sort | Thotsapol Thomrongsuwannakij |
| collection | DOAJ |
| description | Background and Aim: Infectious bursal disease (IBD) or Gumboro disease is one of the most detrimental diseases in the poultry industry worldwide. Previous scientific studies have shown that live IBD vaccination might induce transient immunosuppression, leading to suboptimal vaccine responses, and therefore lack of protection against other infectious diseases; therefore, selecting an IBD vaccine in commercial farms is a concern. This study aims to compare two commercially attenuated IBD vaccines (intermediate and intermediate-plus strains) in terms of safety and antibody response to IBD and Newcastle disease viruses (NDV) in commercial broilers.
Materials and Methods: Overall, 216 Cobb broiler chickens were divided into three groups based on the IBD vaccine strain administered: V217 strain (Group 1), M.B. strain (Group 2), and an unvaccinated group (Group 3). Groups 1 and 2 were orally vaccinated with Hitchner B1 NDV vaccine strain 7 days after IBD vaccination. Blood samples were collected at IBD vaccination day (15 days of age) and at 7, 14, 21, and 28 days post-IBD vaccination. The immunosuppressive effects of the IBD vaccination were determined by NDV antibody response, the bursa:body weight (B:BW) ratio, and the histopathological lesion scores of the bursa of Fabricius. Phylogenetic analysis was also performed.
Results: Phylogenetic analysis revealed that the M.B. strain belonged to a very virulent IBD strain, whereas the V217 strain belonged to a classical IBD virus strain. NDV antibody titers of the two vaccinated groups increased after ND vaccination, reaching their maximum at 14 days post-ND vaccination and decreasing thereafter. The V217 group presented the highest NDV humoral response from 7 days post-vaccination (dpv) to the end of the study. The mean NDV antibody titer of the V217 group was significantly (p<0.05) higher than that of the M.B. group at 14 dpv. In addition, the V217 strain-induced lower bursal lesions post-IBD vaccination and a higher B:BW ratio at 7 and 21 dpv compared to the M.B. group. The higher B:BW ratio, lower bursal lesions, and higher ND antibody response present in the V217 group indicate that the V217 strain induces lower immunosuppressive effects compared to the M.B. strain.
Conclusion: The results of this study indicate that IBD vaccine selection merits consideration, as avoiding the immunosuppressive effects induced by live IBD vaccination and the consequent impact on response to other vaccines is important. |
| first_indexed | 2024-12-22T03:53:34Z |
| format | Article |
| id | doaj.art-cd0e6fd8947b4a7a9f035c2af4e198a0 |
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| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-22T03:53:34Z |
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| publisher | Veterinary World |
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| series | Veterinary World |
| spelling | doaj.art-cd0e6fd8947b4a7a9f035c2af4e198a02022-12-21T18:39:56ZengVeterinary WorldVeterinary World0972-89882231-09162021-01-01141707710.14202/vetworld.2021.70-77Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilersThotsapol Thomrongsuwannakij0https://orcid.org/0000-0001-9015-5134Nataya Charoenvisal1https://orcid.org/0000-0003-3892-3401Niwat Chansiripornchai2https://orcid.org/0000-0002-9633-2880Akkhraratchakumari Veterinary College, Walailak University, Nakorn Si Thammarat 80160, Thailand.Avian Health Research Unit, Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.Avian Health Research Unit, Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.Background and Aim: Infectious bursal disease (IBD) or Gumboro disease is one of the most detrimental diseases in the poultry industry worldwide. Previous scientific studies have shown that live IBD vaccination might induce transient immunosuppression, leading to suboptimal vaccine responses, and therefore lack of protection against other infectious diseases; therefore, selecting an IBD vaccine in commercial farms is a concern. This study aims to compare two commercially attenuated IBD vaccines (intermediate and intermediate-plus strains) in terms of safety and antibody response to IBD and Newcastle disease viruses (NDV) in commercial broilers. Materials and Methods: Overall, 216 Cobb broiler chickens were divided into three groups based on the IBD vaccine strain administered: V217 strain (Group 1), M.B. strain (Group 2), and an unvaccinated group (Group 3). Groups 1 and 2 were orally vaccinated with Hitchner B1 NDV vaccine strain 7 days after IBD vaccination. Blood samples were collected at IBD vaccination day (15 days of age) and at 7, 14, 21, and 28 days post-IBD vaccination. The immunosuppressive effects of the IBD vaccination were determined by NDV antibody response, the bursa:body weight (B:BW) ratio, and the histopathological lesion scores of the bursa of Fabricius. Phylogenetic analysis was also performed. Results: Phylogenetic analysis revealed that the M.B. strain belonged to a very virulent IBD strain, whereas the V217 strain belonged to a classical IBD virus strain. NDV antibody titers of the two vaccinated groups increased after ND vaccination, reaching their maximum at 14 days post-ND vaccination and decreasing thereafter. The V217 group presented the highest NDV humoral response from 7 days post-vaccination (dpv) to the end of the study. The mean NDV antibody titer of the V217 group was significantly (p<0.05) higher than that of the M.B. group at 14 dpv. In addition, the V217 strain-induced lower bursal lesions post-IBD vaccination and a higher B:BW ratio at 7 and 21 dpv compared to the M.B. group. The higher B:BW ratio, lower bursal lesions, and higher ND antibody response present in the V217 group indicate that the V217 strain induces lower immunosuppressive effects compared to the M.B. strain. Conclusion: The results of this study indicate that IBD vaccine selection merits consideration, as avoiding the immunosuppressive effects induced by live IBD vaccination and the consequent impact on response to other vaccines is important.http://www.veterinaryworld.org/Vol.14/January-2021/9.pdfbroilersimmunosuppressive effectsinfectious bursal diseasevaccination |
| spellingShingle | Thotsapol Thomrongsuwannakij Nataya Charoenvisal Niwat Chansiripornchai Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers Veterinary World broilers immunosuppressive effects infectious bursal disease vaccination |
| title | Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| title_full | Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| title_fullStr | Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| title_full_unstemmed | Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| title_short | Comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| title_sort | comparison of two attenuated infectious bursal disease vaccine strains focused on safety and antibody response in commercial broilers |
| topic | broilers immunosuppressive effects infectious bursal disease vaccination |
| url | http://www.veterinaryworld.org/Vol.14/January-2021/9.pdf |
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