IGFBP-1 forms associated with placental cell membranes
Fetal growth in utero depends on the proper development and function of the placenta. Insulin-like growth factors (IGFs) are critically involved in placental development. During pregnancy, an IGF-binding protein, IGFBP-1, which is produced by maternal decidua, plays an important role in the control...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2009-07-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.rs/JSCS/Vol74/No7/01_4366_3869.pdf |
| _version_ | 1819034472857731072 |
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| author | ROMANA MASNIKOSA BOGOVID ŽIVKOVIĆ OLGICA NEDIĆ |
| author_facet | ROMANA MASNIKOSA BOGOVID ŽIVKOVIĆ OLGICA NEDIĆ |
| author_sort | ROMANA MASNIKOSA |
| collection | DOAJ |
| description | Fetal growth in utero depends on the proper development and function of the placenta. Insulin-like growth factors (IGFs) are critically involved in placental development. During pregnancy, an IGF-binding protein, IGFBP-1, which is produced by maternal decidua, plays an important role in the control of the bioavailability of IGFs. It has recently been proposed that cleavage of decidual IGFBP-1 by matrix metalloproteases is a novel mechanism in the control of placental development. The presence of IGFBP-1 in solubilized placental cell membranes, i.e. its association with the membranes, was detected in an earlier work. Herein, it is shown that IGFBP-1 from the solubilized membranes forms dimers, as well as high molecular mass complexes. IGFBP-1 dimers preferably contain the non-phosphorylated form of IGFBP-1. The high molecular mass forms are polymers of IGFBP-1 or its complexes with other membrane proteins. Dimerization of IGFBP-1, together with its association with the placental cell membrane, could serve as an additional mechanism of the regulation of IGF availability to the type 1 IGF receptors. |
| first_indexed | 2024-12-21T07:34:17Z |
| format | Article |
| id | doaj.art-cd0ebc13e22c4881a17567c83b735387 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-21T07:34:17Z |
| publishDate | 2009-07-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-cd0ebc13e22c4881a17567c83b7353872022-12-21T19:11:29ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392009-07-01747707716IGFBP-1 forms associated with placental cell membranesROMANA MASNIKOSABOGOVID ŽIVKOVIĆOLGICA NEDIĆFetal growth in utero depends on the proper development and function of the placenta. Insulin-like growth factors (IGFs) are critically involved in placental development. During pregnancy, an IGF-binding protein, IGFBP-1, which is produced by maternal decidua, plays an important role in the control of the bioavailability of IGFs. It has recently been proposed that cleavage of decidual IGFBP-1 by matrix metalloproteases is a novel mechanism in the control of placental development. The presence of IGFBP-1 in solubilized placental cell membranes, i.e. its association with the membranes, was detected in an earlier work. Herein, it is shown that IGFBP-1 from the solubilized membranes forms dimers, as well as high molecular mass complexes. IGFBP-1 dimers preferably contain the non-phosphorylated form of IGFBP-1. The high molecular mass forms are polymers of IGFBP-1 or its complexes with other membrane proteins. Dimerization of IGFBP-1, together with its association with the placental cell membrane, could serve as an additional mechanism of the regulation of IGF availability to the type 1 IGF receptors.http://www.shd.org.rs/JSCS/Vol74/No7/01_4366_3869.pdfIGFBP-1 dimersplacentaIGFBP-1 phosphoisoforms |
| spellingShingle | ROMANA MASNIKOSA BOGOVID ŽIVKOVIĆ OLGICA NEDIĆ IGFBP-1 forms associated with placental cell membranes Journal of the Serbian Chemical Society IGFBP-1 dimers placenta IGFBP-1 phosphoisoforms |
| title | IGFBP-1 forms associated with placental cell membranes |
| title_full | IGFBP-1 forms associated with placental cell membranes |
| title_fullStr | IGFBP-1 forms associated with placental cell membranes |
| title_full_unstemmed | IGFBP-1 forms associated with placental cell membranes |
| title_short | IGFBP-1 forms associated with placental cell membranes |
| title_sort | igfbp 1 forms associated with placental cell membranes |
| topic | IGFBP-1 dimers placenta IGFBP-1 phosphoisoforms |
| url | http://www.shd.org.rs/JSCS/Vol74/No7/01_4366_3869.pdf |
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