Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis
Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000600462&lng=en&tlng=en |
| _version_ | 1818916926648221696 |
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| author | Marco Antonio dos Anjos Corvo Claudia Alessandra Eckley Luis Vicente Rizzo Luiz Roberto Sardinha Tomas Navarro Rodriguez Ivo Bussoloti Filho |
| author_facet | Marco Antonio dos Anjos Corvo Claudia Alessandra Eckley Luis Vicente Rizzo Luiz Roberto Sardinha Tomas Navarro Rodriguez Ivo Bussoloti Filho |
| author_sort | Marco Antonio dos Anjos Corvo |
| collection | DOAJ |
| description | Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux. Objective: To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls. Methods: This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations. Results: The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls. Conclusion: Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group. |
| first_indexed | 2024-12-20T00:25:56Z |
| format | Article |
| id | doaj.art-cd0ed27978cf48d28e3bb8017e114db7 |
| institution | Directory Open Access Journal |
| issn | 1808-8686 |
| language | English |
| last_indexed | 2024-12-20T00:25:56Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-cd0ed27978cf48d28e3bb8017e114db72022-12-21T20:00:04ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86862014-12-0180646246910.1016/j.bjorl.2014.08.006S1808-86942014000600462Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitisMarco Antonio dos Anjos CorvoClaudia Alessandra EckleyLuis Vicente RizzoLuiz Roberto SardinhaTomas Navarro RodriguezIvo Bussoloti FilhoIntroduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux. Objective: To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls. Methods: This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations. Results: The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls. Conclusion: Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000600462&lng=en&tlng=enXerostomiaRefluxo laringofaríngeoSíndrome de SjögrenSalivaFator de crescimento epidérmicoFator transformador de crescimento alfa |
| spellingShingle | Marco Antonio dos Anjos Corvo Claudia Alessandra Eckley Luis Vicente Rizzo Luiz Roberto Sardinha Tomas Navarro Rodriguez Ivo Bussoloti Filho Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis Brazilian Journal of Otorhinolaryngology Xerostomia Refluxo laringofaríngeo Síndrome de Sjögren Saliva Fator de crescimento epidérmico Fator transformador de crescimento alfa |
| title | Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis |
| title_full | Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis |
| title_fullStr | Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis |
| title_full_unstemmed | Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis |
| title_short | Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis |
| title_sort | salivary transforming growth factor alpha in patients with sjogren s syndrome and reflux laryngitis |
| topic | Xerostomia Refluxo laringofaríngeo Síndrome de Sjögren Saliva Fator de crescimento epidérmico Fator transformador de crescimento alfa |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000600462&lng=en&tlng=en |
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