Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals
Abstract We aimed to investigate the relationship between spatiotemporal changes of amyloid deposition and Alzheimer’s disease (AD) profiles in cognitively normal (CN) and those with mild cognitive impairment (MCI). Using a data-driven method and amyloid-PET data, we identified and validated two sub...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02328-2 |
| _version_ | 1811171530646749184 |
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| author | Yuqing Sun Yuxin Zhao Ke Hu Meng Wang Yong Liu Bing Liu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Yuqing Sun Yuxin Zhao Ke Hu Meng Wang Yong Liu Bing Liu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Yuqing Sun |
| collection | DOAJ |
| description | Abstract We aimed to investigate the relationship between spatiotemporal changes of amyloid deposition and Alzheimer’s disease (AD) profiles in cognitively normal (CN) and those with mild cognitive impairment (MCI). Using a data-driven method and amyloid-PET data, we identified and validated two subtypes in two independent datasets (discovery dataset: N = 548, age = 72.4 ± 6.78, 49% female; validation dataset: N = 348, age = 74.9 ± 8.16, 47% female) from the Alzheimer’s Disease Neuroimaging Initiative across a range of individuals who were CN or had MCI. The two subtypes showed distinct regional progression patterns and presented distinct genetic, clinical and biomarker characteristics. The cortex-priority subtype was more likely to show typical clinical syndromes of symptomatic AD and vice versa. Furthermore, the regional progression patterns were associated with clinical and biomarker profiles. In sum, our findings suggest that the spatiotemporal variants of amyloid depositions are in close association with disease trajectories; these findings may provide insight into the disease monitoring and enrollment of therapeutic trials in AD. |
| first_indexed | 2024-04-10T17:16:36Z |
| format | Article |
| id | doaj.art-cd0fc2cf98a44f758327a668a9f9a2ee |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-10T17:16:36Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-cd0fc2cf98a44f758327a668a9f9a2ee2023-02-05T12:24:44ZengNature Publishing GroupTranslational Psychiatry2158-31882023-02-011311910.1038/s41398-023-02328-2Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individualsYuqing Sun0Yuxin Zhao1Ke Hu2Meng Wang3Yong Liu4Bing Liu5for the Alzheimer’s Disease Neuroimaging InitiativeState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversitySchool of Artificial Intelligence, University of Chinese Academy of SciencesSchool of Artificial Intelligence, University of Chinese Academy of SciencesState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversitySchool of Artificial Intelligence, Beijing University of Posts and TelecommunicationsState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversityAbstract We aimed to investigate the relationship between spatiotemporal changes of amyloid deposition and Alzheimer’s disease (AD) profiles in cognitively normal (CN) and those with mild cognitive impairment (MCI). Using a data-driven method and amyloid-PET data, we identified and validated two subtypes in two independent datasets (discovery dataset: N = 548, age = 72.4 ± 6.78, 49% female; validation dataset: N = 348, age = 74.9 ± 8.16, 47% female) from the Alzheimer’s Disease Neuroimaging Initiative across a range of individuals who were CN or had MCI. The two subtypes showed distinct regional progression patterns and presented distinct genetic, clinical and biomarker characteristics. The cortex-priority subtype was more likely to show typical clinical syndromes of symptomatic AD and vice versa. Furthermore, the regional progression patterns were associated with clinical and biomarker profiles. In sum, our findings suggest that the spatiotemporal variants of amyloid depositions are in close association with disease trajectories; these findings may provide insight into the disease monitoring and enrollment of therapeutic trials in AD.https://doi.org/10.1038/s41398-023-02328-2 |
| spellingShingle | Yuqing Sun Yuxin Zhao Ke Hu Meng Wang Yong Liu Bing Liu for the Alzheimer’s Disease Neuroimaging Initiative Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals Translational Psychiatry |
| title | Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| title_full | Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| title_fullStr | Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| title_full_unstemmed | Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| title_short | Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| title_sort | distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals |
| url | https://doi.org/10.1038/s41398-023-02328-2 |
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