Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstaki Cells Reveal New Insights on Bacterial Pathogenesis in Insects

Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstaki Cells Reveal New Insights on Bacterial Pathogenesis in Insects

ABSTRACT The spore-forming bacterium Bacillus thuringiensis (Bt) of the Bacillus cereus group uses toxin-opened breaches at the insect midgut epithelium to infest the hemolymph, where it can rapidly propagate despite antimicrobial host defenses and induce host death by acute septicemia. The response...

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Bibliographic Details
Main Authors: Yanyan Sun, Linlin Yang, Lianet Rodríguez-Cabrera, Yushan Ding, Chaoliang Leng, Huili Qiao, Siliang Huang, Yunchao Kan, Lunguang Yao, Denis J. Wright, Dandan Li, Camilo Ayra-Pardo
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
TMT-based quantitative proteomics
insect pathogen
septicemia
oxidative stress
virulence
biofilm formation
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00604-21

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