Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway

Abstract Objective We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO). Materials and methods Rats were randomly assigned to five groups: control, ISO, ISO + propranolol (10 mg/kg), ISO + TMP (10 mg/kg...

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Bibliographic Details
Main Authors: Qing Yang, Dan Dan Huang, Da Guang Li, Bo Chen, Ling Min Zhang, Cui Ling Yuan, Hong Hong Huang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
Tetramethylpyrazine
Myocardial ischemia
PI3K
Akt
GSK-3β
Online Access:http://link.springer.com/article/10.1186/s11658-019-0141-5

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