LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin
Clostridium novyi alpha-toxin (Tcnα) also uses LRP1 and Megalin as cellular entry receptors besides LDLR, and this might be a response to cell-type dependent receptor availability for the exotoxin.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03873-0 |
| _version_ | 1828735278657830912 |
|---|---|
| author | Yao Zhou Danyang Li Diyin Li Aizhong Chen Liuqing He Jianhua Luo Liang Tao |
| author_facet | Yao Zhou Danyang Li Diyin Li Aizhong Chen Liuqing He Jianhua Luo Liang Tao |
| author_sort | Yao Zhou |
| collection | DOAJ |
| description | Clostridium novyi alpha-toxin (Tcnα) also uses LRP1 and Megalin as cellular entry receptors besides LDLR, and this might be a response to cell-type dependent receptor availability for the exotoxin. |
| first_indexed | 2024-04-12T23:02:48Z |
| format | Article |
| id | doaj.art-cd14c64acda7416b9bf2ce109490c61c |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T23:02:48Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-cd14c64acda7416b9bf2ce109490c61c2022-12-22T03:13:00ZengNature PortfolioCommunications Biology2399-36422022-09-01511910.1038/s42003-022-03873-0LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxinYao Zhou0Danyang Li1Diyin Li2Aizhong Chen3Liuqing He4Jianhua Luo5Liang Tao6College of Life Sciences, Zhejiang UniversityCollege of Life Sciences, Zhejiang UniversityCollege of Life Sciences, Zhejiang UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityCollege of Life Sciences, Zhejiang UniversityClostridium novyi alpha-toxin (Tcnα) also uses LRP1 and Megalin as cellular entry receptors besides LDLR, and this might be a response to cell-type dependent receptor availability for the exotoxin.https://doi.org/10.1038/s42003-022-03873-0 |
| spellingShingle | Yao Zhou Danyang Li Diyin Li Aizhong Chen Liuqing He Jianhua Luo Liang Tao LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin Communications Biology |
| title | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin |
| title_full | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin |
| title_fullStr | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin |
| title_full_unstemmed | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin |
| title_short | LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin |
| title_sort | ldlr lrp1 and megalin redundantly participate in the uptake of clostridium novyi alpha toxin |
| url | https://doi.org/10.1038/s42003-022-03873-0 |
| work_keys_str_mv | AT yaozhou ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT danyangli ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT diyinli ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT aizhongchen ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT liuqinghe ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT jianhualuo ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin AT liangtao ldlrlrp1andmegalinredundantlyparticipateintheuptakeofclostridiumnovyialphatoxin |