Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction
ABSTRACT<br /> A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow a...
| Päätekijät: | , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | Arabic |
| Julkaistu: |
College of Education for Pure Sciences
2009-03-01
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| Sarja: | مجلة التربية والعلم |
| Aiheet: | |
| Linkit: | https://edusj.mosuljournals.com/article_57438_6b60176c34ace90398b42a4984b4724a.pdf |
| _version_ | 1831762260142325760 |
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| author | Nabeel Othman Shilan Omer |
| author_facet | Nabeel Othman Shilan Omer |
| author_sort | Nabeel Othman |
| collection | DOAJ |
| description | ABSTRACT<br /> A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow azo dye with maximum absorption at 387 nm. Beer’s law is obeyed in the concentration range of 20-280g of bromhexine-HCl in a final volume of 25 ml (0.8- 11.2 ppm) with a molar absorptivity of 1.031104 L.mol-1.cm-1, a relative error of -0.36 to +0.72 % and <br /> a relative standard deviation of 1.07 to 1.72 %, depending on the concentration level of bromhexine-HCl. The method has been successfully applied for the assay of bromhexine-HCl in various pharmaceutical preparations. |
| first_indexed | 2024-12-22T05:03:45Z |
| format | Article |
| id | doaj.art-cd17b732b51f470a94996af6e8628a05 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-22T05:03:45Z |
| publishDate | 2009-03-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-cd17b732b51f470a94996af6e8628a052022-12-21T18:38:11ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302009-03-01221193110.33899/edusj.2009.5743857438Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation ReactionNabeel Othman0Shilan Omer1Department of Chemistry, College of Science, University of Mosul, Mosul, IraqDepartment of Chemistry, College of Science, University of Mosul, Mosul, IraqABSTRACT<br /> A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow azo dye with maximum absorption at 387 nm. Beer’s law is obeyed in the concentration range of 20-280g of bromhexine-HCl in a final volume of 25 ml (0.8- 11.2 ppm) with a molar absorptivity of 1.031104 L.mol-1.cm-1, a relative error of -0.36 to +0.72 % and <br /> a relative standard deviation of 1.07 to 1.72 %, depending on the concentration level of bromhexine-HCl. The method has been successfully applied for the assay of bromhexine-HCl in various pharmaceutical preparations.https://edusj.mosuljournals.com/article_57438_6b60176c34ace90398b42a4984b4724a.pdfspectrophotometric determinationbromhexine hydrochlorideazo-dye formation reaction |
| spellingShingle | Nabeel Othman Shilan Omer Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction مجلة التربية والعلم spectrophotometric determination bromhexine hydrochloride azo-dye formation reaction |
| title | Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction |
| title_full | Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction |
| title_fullStr | Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction |
| title_full_unstemmed | Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction |
| title_short | Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction |
| title_sort | spectrophotometric determination of bromhexine hydrochloride by azo dye formation reaction |
| topic | spectrophotometric determination bromhexine hydrochloride azo-dye formation reaction |
| url | https://edusj.mosuljournals.com/article_57438_6b60176c34ace90398b42a4984b4724a.pdf |
| work_keys_str_mv | AT nabeelothman spectrophotometricdeterminationofbromhexinehydrochloridebyazodyeformationreaction AT shilanomer spectrophotometricdeterminationofbromhexinehydrochloridebyazodyeformationreaction |