Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties
Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/7/12166 |
| _version_ | 1819146788305633280 |
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| author | Chia-Wei Chu Chi-Ming Liu Mei-Ing Chung Chung-Yi Chen |
| author_facet | Chia-Wei Chu Chi-Ming Liu Mei-Ing Chung Chung-Yi Chen |
| author_sort | Chia-Wei Chu |
| collection | DOAJ |
| description | Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (−)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (−)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening. |
| first_indexed | 2024-12-22T13:19:29Z |
| format | Article |
| id | doaj.art-cd1a584bf8144e36b8a06076953e2e27 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T13:19:29Z |
| publishDate | 2015-07-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd1a584bf8144e36b8a06076953e2e272022-12-21T18:24:30ZengMDPI AGMolecules1420-30492015-07-01207121661217410.3390/molecules200712166molecules200712166Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic PropertiesChia-Wei Chu0Chi-Ming Liu1Mei-Ing Chung2Chung-Yi Chen3School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, TaiwanSeven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (−)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (−)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.http://www.mdpi.com/1420-3049/20/7/12166Michelia compressa var. lanyuensisMagnoliaceaetyrosinase activitymelanin |
| spellingShingle | Chia-Wei Chu Chi-Ming Liu Mei-Ing Chung Chung-Yi Chen Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties Molecules Michelia compressa var. lanyuensis Magnoliaceae tyrosinase activity melanin |
| title | Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties |
| title_full | Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties |
| title_fullStr | Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties |
| title_full_unstemmed | Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties |
| title_short | Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties |
| title_sort | biofunctional constituents from michelia compressa var lanyuensis with anti melanogenic properties |
| topic | Michelia compressa var. lanyuensis Magnoliaceae tyrosinase activity melanin |
| url | http://www.mdpi.com/1420-3049/20/7/12166 |
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