Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.

Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) and the nuclear receptor co-repressor1 (NCoR1) are paralogs and regulate nuclear receptor (NR) function through the recruitment of a multiprotein complex that includes histone deacetylase activity. Previous genetic strategies which...

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Bibliographic Details
Main Authors: Hiroaki Shimizu, Yu Lu, Kristen R Vella, Federico Damilano, Inna Astapova, Izuki Amano, Megan Ritter, Molly R Gallop, Anthony N Rosenzweig, Ronald N Cohen, Anthony N Hollenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0220717

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