Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations
Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique propert...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/4/366 |
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| author | Helena Laronha Inês Carpinteiro Jaime Portugal Ana Azul Mário Polido Krasimira T. Petrova Madalena Salema-Oom Isabel Barahona Jorge Caldeira |
| author_facet | Helena Laronha Inês Carpinteiro Jaime Portugal Ana Azul Mário Polido Krasimira T. Petrova Madalena Salema-Oom Isabel Barahona Jorge Caldeira |
| author_sort | Helena Laronha |
| collection | DOAJ |
| description | Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1; -2; -8; -9 and -13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release. |
| first_indexed | 2024-03-10T12:43:52Z |
| format | Article |
| id | doaj.art-cd1b448a140346a2becf70610cb4e713 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T12:43:52Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cd1b448a140346a2becf70610cb4e7132023-11-21T13:39:56ZengMDPI AGBiomedicines2227-90592021-03-019436610.3390/biomedicines9040366Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental RestorationsHelena Laronha0Inês Carpinteiro1Jaime Portugal2Ana Azul3Mário Polido4Krasimira T. Petrova5Madalena Salema-Oom6Isabel Barahona7Jorge Caldeira8Centro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalUnidade de Investigação em Ciências Orais e Biomédicas (UICOB), Faculdade de Medicina Dentária, Universidade de Lisboa, Rua Professora Teresa Ambrósio, 1600-177 Lisboa, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalUCIBIO and LAQV, Requimte, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalCentro de investigação interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalCollagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1; -2; -8; -9 and -13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.https://www.mdpi.com/2227-9059/9/4/366matrixmetalloproteinasesInhibitors of matrix metalloproteinasesCytotoxicity |
| spellingShingle | Helena Laronha Inês Carpinteiro Jaime Portugal Ana Azul Mário Polido Krasimira T. Petrova Madalena Salema-Oom Isabel Barahona Jorge Caldeira Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations Biomedicines matrix metalloproteinases Inhibitors of matrix metalloproteinases Cytotoxicity |
| title | Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations |
| title_full | Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations |
| title_fullStr | Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations |
| title_full_unstemmed | Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations |
| title_short | Polymerizable Matrix Metalloproteinases’ Inhibitors with Potential Application for Dental Restorations |
| title_sort | polymerizable matrix metalloproteinases inhibitors with potential application for dental restorations |
| topic | matrix metalloproteinases Inhibitors of matrix metalloproteinases Cytotoxicity |
| url | https://www.mdpi.com/2227-9059/9/4/366 |
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