COVID-19 and androgenic status: testosterone or dihydrotestosterone have a pivotal role?
The aim of our study is analysis of the androgenic status including testosterone (T) and dihydrotestosterone (DHT) in men hospitalized with coronavirus disease 2019 (COVID-19) and them relationship with the course of the disease. This is a monocentric prospective study performed on 125 male patie...
| Główni autorzy: | , , , , , , , , , , , , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
MRE Press
2023-02-01
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| Seria: | Journal of Men's Health |
| Hasła przedmiotowe: | |
| Dostęp online: | https://oss.jomh.org/files/article/20230130-24/pdf/JOMH15378.pdf |
| _version_ | 1827359691119788032 |
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| author | Kamalov Аrmais Mareev Viacheslav Orlova Iana Mareev Yury Begrambekova Yulia Pavlova Zukhra Plisyk Alina Samokhodskaya Larisa Mershina Elena Ohobotov Dmitry Nesterova Olga Strigunov Andrey Tsurskaya Daria |
| author_facet | Kamalov Аrmais Mareev Viacheslav Orlova Iana Mareev Yury Begrambekova Yulia Pavlova Zukhra Plisyk Alina Samokhodskaya Larisa Mershina Elena Ohobotov Dmitry Nesterova Olga Strigunov Andrey Tsurskaya Daria |
| author_sort | Kamalov Аrmais |
| collection | DOAJ |
| description | The aim of our study is analysis of the androgenic status including testosterone (T)
and dihydrotestosterone (DHT) in men hospitalized with coronavirus disease 2019 (COVID-19) and them
relationship with the course of the disease. This is a
monocentric prospective study performed on 125 male patients hospitalized for
COVID-19. We conducted hematological examination, blood biochemical profile,
hemostasis analysis and hormonal examination (T and
DHT levels) lung and chest computed tomography and also
assessed outcomes of hospitalization. Low DHT serum level was found only
in 18 patients (14.4%). Subjects with low DHT were significantly older compare
to subjects with normal DHT. At the same time in patients with normal DHT white
blood cells (WBC) count, neutrophils at admission were higher than in patients
with low DHT. No correlation was observed between T and DHT serum blood levels.
C-reactive protein (CRP) has a weak positive correlation of DHT serum blood
concentration (r = 0.22; p = 0.016). The inverse pattern was obtained
for T serum blood concentration (r = −0.285; p = 0.001). After divided
all males according to T concentrations we conducted next correlation analysis
for DHT and CRP in two different groups: with normal T levels and with low T
levels. We found that in males with normal T DHT levels are not correlated with
CRP (r = 0.095; p = 0.462). However, in males with low T DHT and CRP had
weak positive correlation with r = 0.317 (p = 0.012). Higher DHT concentrations are associated with higher CRP levels, however correlation is weak and in patients with normal T is absent, that may indicate
anti-inflammatory effect of T and possible proinflammatory effect of DHT. |
| first_indexed | 2024-03-08T06:33:44Z |
| format | Article |
| id | doaj.art-cd1bbfacff3f459e81f0505b86337c0e |
| institution | Directory Open Access Journal |
| issn | 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T06:33:44Z |
| publishDate | 2023-02-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-cd1bbfacff3f459e81f0505b86337c0e2024-02-03T10:58:22ZengMRE PressJournal of Men's Health1875-68592023-02-01191334210.22514/jomh.2023.006S1875-6867(23)00464-5COVID-19 and androgenic status: testosterone or dihydrotestosterone have a pivotal role?Kamalov Аrmais0Mareev Viacheslav1Orlova Iana2Mareev Yury3Begrambekova Yulia4Pavlova Zukhra5Plisyk Alina6Samokhodskaya Larisa7Mershina Elena8Ohobotov Dmitry9Nesterova Olga10Strigunov Andrey11Tsurskaya Daria12Department of Urology and Andrology, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Age-Associated Diseases, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Age-Associated Diseases, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Age-Associated Diseases, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaLaboratory Diagnostics Department, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Urology and Andrology, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Urology and Andrology, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaDepartment of Urology and Andrology, Moscow Research and Education Center of the Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaThe aim of our study is analysis of the androgenic status including testosterone (T) and dihydrotestosterone (DHT) in men hospitalized with coronavirus disease 2019 (COVID-19) and them relationship with the course of the disease. This is a monocentric prospective study performed on 125 male patients hospitalized for COVID-19. We conducted hematological examination, blood biochemical profile, hemostasis analysis and hormonal examination (T and DHT levels) lung and chest computed tomography and also assessed outcomes of hospitalization. Low DHT serum level was found only in 18 patients (14.4%). Subjects with low DHT were significantly older compare to subjects with normal DHT. At the same time in patients with normal DHT white blood cells (WBC) count, neutrophils at admission were higher than in patients with low DHT. No correlation was observed between T and DHT serum blood levels. C-reactive protein (CRP) has a weak positive correlation of DHT serum blood concentration (r = 0.22; p = 0.016). The inverse pattern was obtained for T serum blood concentration (r = −0.285; p = 0.001). After divided all males according to T concentrations we conducted next correlation analysis for DHT and CRP in two different groups: with normal T levels and with low T levels. We found that in males with normal T DHT levels are not correlated with CRP (r = 0.095; p = 0.462). However, in males with low T DHT and CRP had weak positive correlation with r = 0.317 (p = 0.012). Higher DHT concentrations are associated with higher CRP levels, however correlation is weak and in patients with normal T is absent, that may indicate anti-inflammatory effect of T and possible proinflammatory effect of DHT.https://oss.jomh.org/files/article/20230130-24/pdf/JOMH15378.pdfcovid-19testosteronedihydrotestosterone |
| spellingShingle | Kamalov Аrmais Mareev Viacheslav Orlova Iana Mareev Yury Begrambekova Yulia Pavlova Zukhra Plisyk Alina Samokhodskaya Larisa Mershina Elena Ohobotov Dmitry Nesterova Olga Strigunov Andrey Tsurskaya Daria COVID-19 and androgenic status: testosterone or dihydrotestosterone have a pivotal role? Journal of Men's Health covid-19 testosterone dihydrotestosterone |
| title | COVID-19 and androgenic status: testosterone or dihydrotestosterone have
a pivotal role? |
| title_full | COVID-19 and androgenic status: testosterone or dihydrotestosterone have
a pivotal role? |
| title_fullStr | COVID-19 and androgenic status: testosterone or dihydrotestosterone have
a pivotal role? |
| title_full_unstemmed | COVID-19 and androgenic status: testosterone or dihydrotestosterone have
a pivotal role? |
| title_short | COVID-19 and androgenic status: testosterone or dihydrotestosterone have
a pivotal role? |
| title_sort | covid 19 and androgenic status testosterone or dihydrotestosterone have a pivotal role |
| topic | covid-19 testosterone dihydrotestosterone |
| url | https://oss.jomh.org/files/article/20230130-24/pdf/JOMH15378.pdf |
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