Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer
Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-03-01
|
| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2023-0003 |
| _version_ | 1797848532785299456 |
|---|---|
| author | Vidic Zala Goricar Katja Strazisar Branka Besic Nikola Dolzan Vita |
| author_facet | Vidic Zala Goricar Katja Strazisar Branka Besic Nikola Dolzan Vita |
| author_sort | Vidic Zala |
| collection | DOAJ |
| description | Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with outcomes of tramadol/paracetamol treatment after breast cancer surgery with axillary lymphadenectomy. |
| first_indexed | 2024-04-09T18:30:13Z |
| format | Article |
| id | doaj.art-cd1cb5443e4d469d8f70f9fc0e1fc722 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-04-09T18:30:13Z |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-cd1cb5443e4d469d8f70f9fc0e1fc7222023-04-11T17:19:28ZengSciendoRadiology and Oncology1581-32072023-03-0157111112010.2478/raon-2023-0003Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancerVidic Zala0Goricar Katja1Strazisar Branka2Besic Nikola3Dolzan Vita4Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaInstitute of Oncology, Ljubljana, SloveniaInstitute of Oncology, Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaTramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with outcomes of tramadol/paracetamol treatment after breast cancer surgery with axillary lymphadenectomy.https://doi.org/10.2478/raon-2023-0003breast cancer surgerymirnaoprm1pain treatmenttramadol |
| spellingShingle | Vidic Zala Goricar Katja Strazisar Branka Besic Nikola Dolzan Vita Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer Radiology and Oncology breast cancer surgery mirna oprm1 pain treatment tramadol |
| title | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| title_full | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| title_fullStr | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| title_full_unstemmed | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| title_short | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| title_sort | association of oprm1 mir23b and mir107 genetic variability with acute pain chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
| topic | breast cancer surgery mirna oprm1 pain treatment tramadol |
| url | https://doi.org/10.2478/raon-2023-0003 |
| work_keys_str_mv | AT vidiczala associationofoprm1mir23bandmir107geneticvariabilitywithacutepainchronicpainandadverseeffectsafterpostoperativetramadolandparacetamoltreatmentinbreastcancer AT goricarkatja associationofoprm1mir23bandmir107geneticvariabilitywithacutepainchronicpainandadverseeffectsafterpostoperativetramadolandparacetamoltreatmentinbreastcancer AT strazisarbranka associationofoprm1mir23bandmir107geneticvariabilitywithacutepainchronicpainandadverseeffectsafterpostoperativetramadolandparacetamoltreatmentinbreastcancer AT besicnikola associationofoprm1mir23bandmir107geneticvariabilitywithacutepainchronicpainandadverseeffectsafterpostoperativetramadolandparacetamoltreatmentinbreastcancer AT dolzanvita associationofoprm1mir23bandmir107geneticvariabilitywithacutepainchronicpainandadverseeffectsafterpostoperativetramadolandparacetamoltreatmentinbreastcancer |