Discovery of Novel GMPS Inhibitors of <i>Candidatus</i> Liberibacter Asiaticus by Structure Based Design and Enzyme Kinetic

Discovery of Novel GMPS Inhibitors of <i>Candidatus</i> Liberibacter Asiaticus by Structure Based Design and Enzyme Kinetic

Citrus production is facing an unprecedented problem because of huanglongbing (HLB) disease. Presently, no effective HLB-easing method is available when citrus becomes infected. Guanosine 5′-monophosphate synthetase (GMPS) is a key protein in the de novo synthesis of guanine nucleotides. GMPS is use...

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Bibliographic Details
Main Authors: Jing Nan, Shaoran Zhang, Ping Zhan, Ling Jiang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biology
Subjects:
<i>Candidatus</i> Liberibacter asiaticus
guanosine 5′-monophosphate synthetase
virtual screening
molecular docking
enzyme activity
Online Access:https://www.mdpi.com/2079-7737/10/7/594

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