Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo
Galangin, a non-toxic phytochemical, is known to have a variety of therapeutic uses. This study looked into the role of inclusion complexes of galangin/β-cyclodextrin in increasing antioxidant activity over pure galangin. The role of this inclusion complex in increasing antioxidant activity in compa...
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| Format: | Article |
| Language: | English |
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University of Technology, Baghdad
2023-03-01
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| Series: | Journal of Applied Sciences and Nanotechnology |
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| Online Access: | https://jasn.uotechnology.edu.iq/article_22917_936d269d10b727d5333a8aad8aa2fb87.pdf |
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| author | Zainab Abbas Ghassan Sulaiman Majid Jabir Hamdoon Mohammed Salman Mohammed |
| author_facet | Zainab Abbas Ghassan Sulaiman Majid Jabir Hamdoon Mohammed Salman Mohammed |
| author_sort | Zainab Abbas |
| collection | DOAJ |
| description | Galangin, a non-toxic phytochemical, is known to have a variety of therapeutic uses. This study looked into the role of inclusion complexes of galangin/β-cyclodextrin in increasing antioxidant activity over pure galangin. The role of this inclusion complex in increasing antioxidant activity in comparison to pure galangin. In this study, hydrogen peroxide assays were used in vitro. Galangin demonstrated concentration-dependent scavenging action in the 2-50 µg mL<sup>-1</sup> range, with the highest level of activity possible 92.00% at 50 µg mL<sup>-1</sup>. In pure galangin, a decrease of 85.00% was observed. The ferric thiocyanate lipoperoxidation method was clarified by using galangin and galangin/β-cyclodextrin and demonstrated concentration-dependent suppress lipid peroxidation in the 2-50 µg mL<sup>-1</sup> range, at 50 µg mL<sup>-1</sup>, the highest level of activity was 70.00%. A 60.00% decrease in pure galangin was observed. Xanthine oxidase activity using uric acid was given. The co-incubation of galangin and galangin/β-cyclodextrin inhibited xanthine oxidase activity in a concentration-dependent manner in 2-50 µg mL<sup>-1</sup> range, at 50 µg mL<sup>-1</sup>, the highest level of activity was 90.00 %. Pure galangin showed an 82.00 % decrease. There were no significant differences in absolute weight of mice organs and hematological parameters between pure galangin and galangin/ β-cyclodextrin when used concentration 80 mg kg<sup>-1</sup>, compared to control group. According to the findings, galangin combined with β-cyclodextrin has excellent properties as a therapeutic agent and food supplement. |
| first_indexed | 2024-04-10T00:45:27Z |
| format | Article |
| id | doaj.art-cd1e4302c59048e0baf5bf80bc3c07f5 |
| institution | Directory Open Access Journal |
| issn | 2788-6867 |
| language | English |
| last_indexed | 2024-04-10T00:45:27Z |
| publishDate | 2023-03-01 |
| publisher | University of Technology, Baghdad |
| record_format | Article |
| series | Journal of Applied Sciences and Nanotechnology |
| spelling | doaj.art-cd1e4302c59048e0baf5bf80bc3c07f52023-03-13T22:31:29ZengUniversity of Technology, BaghdadJournal of Applied Sciences and Nanotechnology2788-68672023-03-0131808910.53293/jasn.2022.4876.115722917Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in VivoZainab Abbas0Ghassan Sulaiman1Majid Jabir2Hamdoon Mohammed3Salman Mohammed4Division of Biotechnology, Department of Applied Sciences, University of Technology – IraqDivision of Biotechnology, Department of Applied Sciences, University of Technology – IraqDivision of Biotechnology, Department of Applied Sciences, University of Technology – IraqDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University – Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University – EgyptDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University – Saudi ArabiaGalangin, a non-toxic phytochemical, is known to have a variety of therapeutic uses. This study looked into the role of inclusion complexes of galangin/β-cyclodextrin in increasing antioxidant activity over pure galangin. The role of this inclusion complex in increasing antioxidant activity in comparison to pure galangin. In this study, hydrogen peroxide assays were used in vitro. Galangin demonstrated concentration-dependent scavenging action in the 2-50 µg mL<sup>-1</sup> range, with the highest level of activity possible 92.00% at 50 µg mL<sup>-1</sup>. In pure galangin, a decrease of 85.00% was observed. The ferric thiocyanate lipoperoxidation method was clarified by using galangin and galangin/β-cyclodextrin and demonstrated concentration-dependent suppress lipid peroxidation in the 2-50 µg mL<sup>-1</sup> range, at 50 µg mL<sup>-1</sup>, the highest level of activity was 70.00%. A 60.00% decrease in pure galangin was observed. Xanthine oxidase activity using uric acid was given. The co-incubation of galangin and galangin/β-cyclodextrin inhibited xanthine oxidase activity in a concentration-dependent manner in 2-50 µg mL<sup>-1</sup> range, at 50 µg mL<sup>-1</sup>, the highest level of activity was 90.00 %. Pure galangin showed an 82.00 % decrease. There were no significant differences in absolute weight of mice organs and hematological parameters between pure galangin and galangin/ β-cyclodextrin when used concentration 80 mg kg<sup>-1</sup>, compared to control group. According to the findings, galangin combined with β-cyclodextrin has excellent properties as a therapeutic agent and food supplement.https://jasn.uotechnology.edu.iq/article_22917_936d269d10b727d5333a8aad8aa2fb87.pdfgalanginβ-cyclodextrinantioxidantanimal model |
| spellingShingle | Zainab Abbas Ghassan Sulaiman Majid Jabir Hamdoon Mohammed Salman Mohammed Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo Journal of Applied Sciences and Nanotechnology galangin β-cyclodextrin antioxidant animal model |
| title | Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo |
| title_full | Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo |
| title_fullStr | Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo |
| title_full_unstemmed | Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo |
| title_short | Antioxidant Properties of Galangin with β-cyclodextrin: An in Vitro and in Vivo |
| title_sort | antioxidant properties of galangin with β cyclodextrin an in vitro and in vivo |
| topic | galangin β-cyclodextrin antioxidant animal model |
| url | https://jasn.uotechnology.edu.iq/article_22917_936d269d10b727d5333a8aad8aa2fb87.pdf |
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