The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial
Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/13/3002 |
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| author | D. McCullough T. Harrison K. J. Enright F. Amirabdollahian M. Mazidi K. E. Lane C. E. Stewart I. G. Davies |
| author_facet | D. McCullough T. Harrison K. J. Enright F. Amirabdollahian M. Mazidi K. E. Lane C. E. Stewart I. G. Davies |
| author_sort | D. McCullough |
| collection | DOAJ |
| description | Low-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-throughput NMR spectroscopy. This study aimed to explore the effect of an ad libitum 8-week LCHF diet compared to an HCLF diet on lipids and lipoprotein metabolism and CVD risk factors. For 8 weeks, <i>n</i> = 16 adults were randomly assigned to follow either an LCHF (<i>n</i> = 8, <50 g CHO p/day) or an HCLF diet (<i>n</i> = 8). Fasted blood samples at weeks 0, 4, and 8 were collected and analysed for lipids, lipoprotein subclasses, and energy-related metabolism markers via NMR spectroscopy. The LCHF diet increased (<i>p</i> < 0.05) very small VLDL, IDL, and large HDL cholesterol levels, whereas the HCLF diet increased (<i>p</i> < 0.05) IDL and large LDL cholesterol levels. Following the LCHF diet alone, triglycerides in VLDL and HDL lipoproteins significantly (<i>p</i> < 0.05) decreased, and HDL phospholipids significantly (<i>p</i> < 0.05) increased. Furthermore, the LCHF diet significantly (<i>p</i> < 0.05) increased the large and small HDL particle concentrations compared to the HCLF diet. In conclusion, the LCHF diet may reduce CVD risk factors by reducing triglyceride-rich lipoproteins and improving HDL functionality. |
| first_indexed | 2024-03-11T01:32:38Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T01:32:38Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cd1ff35fa4194c31a23b9ad2932e30082023-11-18T17:15:39ZengMDPI AGNutrients2072-66432023-06-011513300210.3390/nu15133002The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel TrialD. McCullough0T. Harrison1K. J. Enright2F. Amirabdollahian3M. Mazidi4K. E. Lane5C. E. Stewart6I. G. Davies7Carnegie School of Sport, Leeds Beckett University, Leeds LS6 3QS, UKDepartment of Clinical Sciences and Nutrition, University of Chester, Chester CH1 4BJ, UKResearch Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UKSchool of Health and Society, University of Wolverhampton, Wolverhampton WV1 1LY, UKMedical Research Council Population Health Research Unit, University of Oxford, Oxford OX1 7LF, UKResearch Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UKResearch Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UKResearch Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, UKLow-carbohydrate high-fat (LCHF) diets can be just as effective as high-carbohydrate, lower-fat (HCLF) diets for improving cardiovascular disease risk markers. Few studies have compared the effects of the UK HCLF dietary guidelines with an LCHF diet on lipids and lipoprotein metabolism using high-throughput NMR spectroscopy. This study aimed to explore the effect of an ad libitum 8-week LCHF diet compared to an HCLF diet on lipids and lipoprotein metabolism and CVD risk factors. For 8 weeks, <i>n</i> = 16 adults were randomly assigned to follow either an LCHF (<i>n</i> = 8, <50 g CHO p/day) or an HCLF diet (<i>n</i> = 8). Fasted blood samples at weeks 0, 4, and 8 were collected and analysed for lipids, lipoprotein subclasses, and energy-related metabolism markers via NMR spectroscopy. The LCHF diet increased (<i>p</i> < 0.05) very small VLDL, IDL, and large HDL cholesterol levels, whereas the HCLF diet increased (<i>p</i> < 0.05) IDL and large LDL cholesterol levels. Following the LCHF diet alone, triglycerides in VLDL and HDL lipoproteins significantly (<i>p</i> < 0.05) decreased, and HDL phospholipids significantly (<i>p</i> < 0.05) increased. Furthermore, the LCHF diet significantly (<i>p</i> < 0.05) increased the large and small HDL particle concentrations compared to the HCLF diet. In conclusion, the LCHF diet may reduce CVD risk factors by reducing triglyceride-rich lipoproteins and improving HDL functionality.https://www.mdpi.com/2072-6643/15/13/3002lipoproteincardiovascular disease riskdietcarbohydratefatNMR spectroscopy |
| spellingShingle | D. McCullough T. Harrison K. J. Enright F. Amirabdollahian M. Mazidi K. E. Lane C. E. Stewart I. G. Davies The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial Nutrients lipoprotein cardiovascular disease risk diet carbohydrate fat NMR spectroscopy |
| title | The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial |
| title_full | The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial |
| title_fullStr | The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial |
| title_full_unstemmed | The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial |
| title_short | The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial |
| title_sort | effect of carbohydrate restriction on lipids lipoproteins and nuclear magnetic resonance based metabolites caliber a randomised parallel trial |
| topic | lipoprotein cardiovascular disease risk diet carbohydrate fat NMR spectroscopy |
| url | https://www.mdpi.com/2072-6643/15/13/3002 |
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