The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation

The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation

ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane ST2L isoforms. The ligand of ST2 is IL-33, which determines the activation of numerous intracytoplasmic mediators following the binding with ST2L and IL-1RAcP, leading to nuclear signal and cardiovascular effect. Di...

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Bibliographic Details
Main Authors: Giacomina Brunetti, Barbara Barile, Grazia Paola Nicchia, Francesco Onorati, Giovanni Battista Luciani, Antonella Galeone
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
ST2
cardiovascular disease
IL-33
Online Access:https://www.mdpi.com/2227-9059/11/6/1676

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