Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.
BACKGROUND:Valid and reliable outcome measures are needed to determine and compare treatment results of port wine stain (PWS) studies. Besides, uniformity in outcome measures is crucial to enable inter-study comparisons and meta-analyses. This study aimed to assess the heterogeneity in reported PWS...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0235657 |
| _version_ | 1819019437022380032 |
|---|---|
| author | M Ingmar van Raath Sandeep Chohan Albert Wolkerstorfer Chantal M A M van der Horst Jacqueline Limpens Xuan Huang Baoyue Ding Gert Storm René R W J van der Hulst Michal Heger |
| author_facet | M Ingmar van Raath Sandeep Chohan Albert Wolkerstorfer Chantal M A M van der Horst Jacqueline Limpens Xuan Huang Baoyue Ding Gert Storm René R W J van der Hulst Michal Heger |
| author_sort | M Ingmar van Raath |
| collection | DOAJ |
| description | BACKGROUND:Valid and reliable outcome measures are needed to determine and compare treatment results of port wine stain (PWS) studies. Besides, uniformity in outcome measures is crucial to enable inter-study comparisons and meta-analyses. This study aimed to assess the heterogeneity in reported PWS outcome measures by mapping the (clinical) outcome measures currently used in prospective PWS studies. METHODS:OVID MEDLINE, OVID Embase, and CENTRAL were searched for prospective PWS studies published from 2005 to May 2020. Interventional studies with a clinical efficacy assessment were included. Two reviewers independently evaluated methodological quality using a modified Downs and Black checklist. RESULTS:In total, 85 studies comprising 3,310 patients were included in which 94 clinician/observer-reported clinical efficacy assessments had been performed using 46 different scoring systems. Eighty-one- studies employed a global assessment of PWS appearance/improvement, of which -82% was expressed as percentage improvement and categorized in 26 different scoring systems. A wide variety of other global and multi-item scoring systems was identified. As a result of outcome heterogeneity and insufficient data reporting, only 44% of studies could be directly compared. A minority of studies included patient-reported or objective outcomes. Thirteen studies of good quality were found. CONCLUSION:Clinical PWS outcomes are highly heterogeneous, which hampers study comparisons and meta-analyses. Consensus-based development of a core outcome-set would benefit future research and clinical practice, especially considering the lack of high-quality trials. |
| first_indexed | 2024-12-21T03:35:18Z |
| format | Article |
| id | doaj.art-cd21305610f04b8888ba382fb898194e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T03:35:18Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cd21305610f04b8888ba382fb898194e2022-12-21T19:17:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023565710.1371/journal.pone.0235657Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.M Ingmar van RaathSandeep ChohanAlbert WolkerstorferChantal M A M van der HorstJacqueline LimpensXuan HuangBaoyue DingGert StormRené R W J van der HulstMichal HegerBACKGROUND:Valid and reliable outcome measures are needed to determine and compare treatment results of port wine stain (PWS) studies. Besides, uniformity in outcome measures is crucial to enable inter-study comparisons and meta-analyses. This study aimed to assess the heterogeneity in reported PWS outcome measures by mapping the (clinical) outcome measures currently used in prospective PWS studies. METHODS:OVID MEDLINE, OVID Embase, and CENTRAL were searched for prospective PWS studies published from 2005 to May 2020. Interventional studies with a clinical efficacy assessment were included. Two reviewers independently evaluated methodological quality using a modified Downs and Black checklist. RESULTS:In total, 85 studies comprising 3,310 patients were included in which 94 clinician/observer-reported clinical efficacy assessments had been performed using 46 different scoring systems. Eighty-one- studies employed a global assessment of PWS appearance/improvement, of which -82% was expressed as percentage improvement and categorized in 26 different scoring systems. A wide variety of other global and multi-item scoring systems was identified. As a result of outcome heterogeneity and insufficient data reporting, only 44% of studies could be directly compared. A minority of studies included patient-reported or objective outcomes. Thirteen studies of good quality were found. CONCLUSION:Clinical PWS outcomes are highly heterogeneous, which hampers study comparisons and meta-analyses. Consensus-based development of a core outcome-set would benefit future research and clinical practice, especially considering the lack of high-quality trials.https://doi.org/10.1371/journal.pone.0235657 |
| spellingShingle | M Ingmar van Raath Sandeep Chohan Albert Wolkerstorfer Chantal M A M van der Horst Jacqueline Limpens Xuan Huang Baoyue Ding Gert Storm René R W J van der Hulst Michal Heger Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. PLoS ONE |
| title | Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. |
| title_full | Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. |
| title_fullStr | Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. |
| title_full_unstemmed | Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. |
| title_short | Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review. |
| title_sort | clinical outcome measures and scoring systems used in prospective studies of port wine stains a systematic review |
| url | https://doi.org/10.1371/journal.pone.0235657 |
| work_keys_str_mv | AT mingmarvanraath clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT sandeepchohan clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT albertwolkerstorfer clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT chantalmamvanderhorst clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT jacquelinelimpens clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT xuanhuang clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT baoyueding clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT gertstorm clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT renerwjvanderhulst clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview AT michalheger clinicaloutcomemeasuresandscoringsystemsusedinprospectivestudiesofportwinestainsasystematicreview |