Association between Experimental Bacterial Meningitis and Periapical Lesion
Introduction: Mortality and morbidity from bacterial meningitis in African adults is significantly higher than those in better resourced settings. At the same time, the periodontal diseases are highly prevalent and can affect up to 90% of the population. Dental caries in Uganda was recorded in 4...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5986/8477_CE(RA1)_F(T)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Introduction: Mortality and morbidity from bacterial meningitis in
African adults is significantly higher than those in better resourced
settings. At the same time, the periodontal diseases are highly
prevalent and can affect up to 90% of the population. Dental
caries in Uganda was recorded in 40% and 62.5% of the children
and adults, respectively. We hypothesize that pneumococcal
meningitis could interfere in the development of periapical lesion.
The aim of this study was to evaluate periapical lesion in Wistar
rats subjected to pneumococcal meningitis.
Materials and Methods: The animals were divided in control,
control/periapical lesion, meningitis, and meningitis/periapical
lesion groups. The surgical exposure of molars and the infection of
the dental pulp were from the oral environment. Pulp necrosis was
induced on the left mandibular first molars during adulthood. Dental
pulps were exposed by drilling cavities on the central portion of
the occlusal surface with a 1011 HL round bur in high speed to a
depth nearly equal to the bur diameter. Animals were subjected to
behavioral task and evaluation of the size of periodontal ligament.
Data from periodontal ligament space and open field task were
reported as mean ± SEM and analysed by Two-way ANOVA and
paired Student’s t-test, respectively.
Results and Conclusion: Meningitis/periapical increased the
periodontal ligament space by 61% when compared with control/
periapical. In the open-field task, there were no differences
in the number of crossings and rearing movements between
training and test session in meningitis and periapical lesion
groups demonstrating habituation memory impairment. Bacterial
meningitis and periapical lesion may play an important role in
development of cognitive impairment. |
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| ISSN: | 2249-782X 0973-709X |