Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population
Abstract The present study aims to determine the carcinogenic and neurotoxic risks associated with acrylamide intake from cereal products. Analysis on a UPLC–MS/MS spectrometer revealed that oat-based and mixed cereals contain the highest amount of acrylamide among cereal products with levels as hig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Chemistry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13065-020-00705-2 |
| _version_ | 1818294204570271744 |
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| author | Areej Merhi Ghada El-Zakhem Naous Ralph Daher Martine Abboud Mohamad Mroueh Robin I. Taleb |
| author_facet | Areej Merhi Ghada El-Zakhem Naous Ralph Daher Martine Abboud Mohamad Mroueh Robin I. Taleb |
| author_sort | Areej Merhi |
| collection | DOAJ |
| description | Abstract The present study aims to determine the carcinogenic and neurotoxic risks associated with acrylamide intake from cereal products. Analysis on a UPLC–MS/MS spectrometer revealed that oat-based and mixed cereals contain the highest amount of acrylamide among cereal products with levels as high as 271 and 348 μg/kg, respectively. Children were shown to exhibit both carcinogenic and neurotoxic risks regardless of the type of cereal product consumed. For adults above 50 years of age, only consumers of oat-based cereal products seem to exhibit carcinogenic and neurotoxic risks. To avoid a carcinogenic and neurotoxic risk among the Lebanese population, we propose that food processors set the maximum tolerable concentration for acrylamide in cereal products at 94.8 μg/kg product, a value which is threefolds lower than the average acrylamide levels found in this study. Alternatively, and unreasonably, the average Lebanese population and children among the Lebanese population may choose to cut down on cereal consumption by 1.7- and 7.2-folds respectively, should they want to avoid a health hazard as a result of acrylamide intake. The industry should also respond by optimizing the production process in a way to reduce acrylamide levels in cereals. |
| first_indexed | 2024-12-13T03:28:02Z |
| format | Article |
| id | doaj.art-cd218974e3e14c5186ef603a28d21903 |
| institution | Directory Open Access Journal |
| issn | 2661-801X |
| language | English |
| last_indexed | 2024-12-13T03:28:02Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj.art-cd218974e3e14c5186ef603a28d219032022-12-22T00:01:14ZengBMCBMC Chemistry2661-801X2020-08-011411710.1186/s13065-020-00705-2Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese populationAreej Merhi0Ghada El-Zakhem Naous1Ralph Daher2Martine Abboud3Mohamad Mroueh4Robin I. Taleb5School of Arts and Sciences, Department of Natural Sciences, Lebanese American UniversitySchool of Arts and Sciences, Department of Natural Sciences, Lebanese American UniversitySchool of Arts and Sciences, Department of Natural Sciences, Lebanese American UniversityDepartment of Chemistry, University of OxfordSchool of Pharmacy, Department of Pharmaceutical Sciences, Lebanese American UniversitySchool of Arts and Sciences, Department of Natural Sciences, Lebanese American UniversityAbstract The present study aims to determine the carcinogenic and neurotoxic risks associated with acrylamide intake from cereal products. Analysis on a UPLC–MS/MS spectrometer revealed that oat-based and mixed cereals contain the highest amount of acrylamide among cereal products with levels as high as 271 and 348 μg/kg, respectively. Children were shown to exhibit both carcinogenic and neurotoxic risks regardless of the type of cereal product consumed. For adults above 50 years of age, only consumers of oat-based cereal products seem to exhibit carcinogenic and neurotoxic risks. To avoid a carcinogenic and neurotoxic risk among the Lebanese population, we propose that food processors set the maximum tolerable concentration for acrylamide in cereal products at 94.8 μg/kg product, a value which is threefolds lower than the average acrylamide levels found in this study. Alternatively, and unreasonably, the average Lebanese population and children among the Lebanese population may choose to cut down on cereal consumption by 1.7- and 7.2-folds respectively, should they want to avoid a health hazard as a result of acrylamide intake. The industry should also respond by optimizing the production process in a way to reduce acrylamide levels in cereals.http://link.springer.com/article/10.1186/s13065-020-00705-2CerealsAcrylamideCarcinogenicNeurotoxicLC–MS/MSWHO |
| spellingShingle | Areej Merhi Ghada El-Zakhem Naous Ralph Daher Martine Abboud Mohamad Mroueh Robin I. Taleb Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population BMC Chemistry Cereals Acrylamide Carcinogenic Neurotoxic LC–MS/MS WHO |
| title | Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population |
| title_full | Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population |
| title_fullStr | Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population |
| title_full_unstemmed | Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population |
| title_short | Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population |
| title_sort | carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the lebanese population |
| topic | Cereals Acrylamide Carcinogenic Neurotoxic LC–MS/MS WHO |
| url | http://link.springer.com/article/10.1186/s13065-020-00705-2 |
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