How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology
Pandemics caused by viruses have threatened lives of thousands of people. Understanding the complicated process of viral infection provides significantly directive implication to epidemic prevention and control. Viral infection is a complex and diverse process, and substantial studies have been comp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.764516/full |
| _version_ | 1819041810501074944 |
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| author | Wei Liu Daijiao Tang Daijiao Tang Xin-Xin Xu Yan-Jun Liu Yaming Jiu Yaming Jiu |
| author_facet | Wei Liu Daijiao Tang Daijiao Tang Xin-Xin Xu Yan-Jun Liu Yaming Jiu Yaming Jiu |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Pandemics caused by viruses have threatened lives of thousands of people. Understanding the complicated process of viral infection provides significantly directive implication to epidemic prevention and control. Viral infection is a complex and diverse process, and substantial studies have been complemented in exploring the biochemical and molecular interactions between viruses and hosts. However, the physical microenvironment where infections implement is often less considered, and the role of mechanobiology in viral infection remains elusive. Mechanobiology focuses on sensation, transduction, and response to intracellular and extracellular physical factors by tissues, cells, and extracellular matrix. The intracellular cytoskeleton and mechanosensors have been proven to be extensively involved in the virus life cycle. Furthermore, innovative methods based on micro- and nanofabrication techniques are being utilized to control and modulate the physical and chemical cell microenvironment, and to explore how extracellular factors including stiffness, forces, and topography regulate viral infection. Our current review covers how physical factors in the microenvironment coordinate viral infection. Moreover, we will discuss how this knowledge can be harnessed in future research on cross-fields of mechanobiology and virology. |
| first_indexed | 2024-12-21T09:30:55Z |
| format | Article |
| id | doaj.art-cd21fd3e4efc443baf1b324b229b74ca |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-21T09:30:55Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-cd21fd3e4efc443baf1b324b229b74ca2022-12-21T19:08:45ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-10-01910.3389/fbioe.2021.764516764516How Physical Factors Coordinate Virus Infection: A Perspective From MechanobiologyWei Liu0Daijiao Tang1Daijiao Tang2Xin-Xin Xu3Yan-Jun Liu4Yaming Jiu5Yaming Jiu6Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Department of Systems Biology for Medicine, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaThe Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaShanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Department of Systems Biology for Medicine, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Department of Systems Biology for Medicine, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaThe Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaPandemics caused by viruses have threatened lives of thousands of people. Understanding the complicated process of viral infection provides significantly directive implication to epidemic prevention and control. Viral infection is a complex and diverse process, and substantial studies have been complemented in exploring the biochemical and molecular interactions between viruses and hosts. However, the physical microenvironment where infections implement is often less considered, and the role of mechanobiology in viral infection remains elusive. Mechanobiology focuses on sensation, transduction, and response to intracellular and extracellular physical factors by tissues, cells, and extracellular matrix. The intracellular cytoskeleton and mechanosensors have been proven to be extensively involved in the virus life cycle. Furthermore, innovative methods based on micro- and nanofabrication techniques are being utilized to control and modulate the physical and chemical cell microenvironment, and to explore how extracellular factors including stiffness, forces, and topography regulate viral infection. Our current review covers how physical factors in the microenvironment coordinate viral infection. Moreover, we will discuss how this knowledge can be harnessed in future research on cross-fields of mechanobiology and virology.https://www.frontiersin.org/articles/10.3389/fbioe.2021.764516/fullvirus infectionmechanobiologycytoskeletonmechanosensorsshear stresstensile or compressive forces |
| spellingShingle | Wei Liu Daijiao Tang Daijiao Tang Xin-Xin Xu Yan-Jun Liu Yaming Jiu Yaming Jiu How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology Frontiers in Bioengineering and Biotechnology virus infection mechanobiology cytoskeleton mechanosensors shear stress tensile or compressive forces |
| title | How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology |
| title_full | How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology |
| title_fullStr | How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology |
| title_full_unstemmed | How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology |
| title_short | How Physical Factors Coordinate Virus Infection: A Perspective From Mechanobiology |
| title_sort | how physical factors coordinate virus infection a perspective from mechanobiology |
| topic | virus infection mechanobiology cytoskeleton mechanosensors shear stress tensile or compressive forces |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.764516/full |
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