A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions

A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions

The solid tumor microenvironment (TME) suppresses immune responses. Three alterations in the TME converge on a pathway triggered by elevated cyclic AMP (cAMP) that suppresses T cell receptor (TCR) signaling. We developed a phenotypic assay to screen for small molecules that interfere with this pathw...

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Bibliographic Details
Main Authors: David Barrett, Meghan Wyatt, Haim Bar, Mark K. Haynes, Bruce S. Edwards, Larry A. Sklar, Adam Zweifach
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:SLAS Discovery
Subjects:
Cancer
Tumor microenvironment
Immunity
Cell signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555222126596

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