A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort
Abstract Bowel dysfunctions (BD) in multiple sclerosis (MS) are under reported despite their clinical relevance. Scales usually applied do not thoroughly assess constipation and fecal incontinence. Instead, a proper qualitative and quantitative description of these symptoms might have relevant clini...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48317-9 |
| _version_ | 1827581744028581888 |
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| author | Eleonora Tavazzi Antonio Zito Cristina Montomoli Niels Bergsland Elena Colombo Alessandro La Malfa Roberto Bergamaschi |
| author_facet | Eleonora Tavazzi Antonio Zito Cristina Montomoli Niels Bergsland Elena Colombo Alessandro La Malfa Roberto Bergamaschi |
| author_sort | Eleonora Tavazzi |
| collection | DOAJ |
| description | Abstract Bowel dysfunctions (BD) in multiple sclerosis (MS) are under reported despite their clinical relevance. Scales usually applied do not thoroughly assess constipation and fecal incontinence. Instead, a proper qualitative and quantitative description of these symptoms might have relevant clinical and scientific consequences. The aim of this project is to study the prevalence of BD in a cohort of persons with MS (pwMS). Four-hundred and forty-seven pwMS (330 relapsing–remitting MS-RRMS and 117 progressive MS-PMS) were recruited. Three different questionnaires were administered: the neurogenic bowel dysfunction score (NBDS), the Wexner constipation scale (WexCon) and the Wexner incontinence scale (WexInc). All the scales were divided in subscores according to symptom severity. The prevalence of BD, considered as NBDS > 0, was 53.7%. Mean scores in pwMS group were as follows: NBDS 2.6 (SD 3.5), WexInc 1.1 (SD 2.4), WexCon 4.4 (SD 5.9). NBDS, WexCon and WexInc were significantly higher in PMS vs RRMS (p < 0.001), and significantly associated with disease duration, EDSS, multiple sclerosis severity score (p < 0.001), as well as with each other (p < 0.001). Our study confirms the presence of bowel dysfunctions in a large group of pwMS with a wide range of disability and their association with progressive disease phenotype and clinical disability. |
| first_indexed | 2024-03-08T22:40:46Z |
| format | Article |
| id | doaj.art-cd241d55bdc9477794deaadc0cc13298 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:40:46Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cd241d55bdc9477794deaadc0cc132982023-12-17T12:13:32ZengNature PortfolioScientific Reports2045-23222023-12-011311610.1038/s41598-023-48317-9A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohortEleonora Tavazzi0Antonio Zito1Cristina Montomoli2Niels Bergsland3Elena Colombo4Alessandro La Malfa5Roberto Bergamaschi6IRCCS Fondazione Istituto Neurologico C.MondinoIRCCS Fondazione Istituto Neurologico C.MondinoUnit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of PaviaDepartment of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New YorkIRCCS Fondazione Istituto Neurologico C.MondinoIRCCS Fondazione Istituto Neurologico C.MondinoIRCCS Fondazione Istituto Neurologico C.MondinoAbstract Bowel dysfunctions (BD) in multiple sclerosis (MS) are under reported despite their clinical relevance. Scales usually applied do not thoroughly assess constipation and fecal incontinence. Instead, a proper qualitative and quantitative description of these symptoms might have relevant clinical and scientific consequences. The aim of this project is to study the prevalence of BD in a cohort of persons with MS (pwMS). Four-hundred and forty-seven pwMS (330 relapsing–remitting MS-RRMS and 117 progressive MS-PMS) were recruited. Three different questionnaires were administered: the neurogenic bowel dysfunction score (NBDS), the Wexner constipation scale (WexCon) and the Wexner incontinence scale (WexInc). All the scales were divided in subscores according to symptom severity. The prevalence of BD, considered as NBDS > 0, was 53.7%. Mean scores in pwMS group were as follows: NBDS 2.6 (SD 3.5), WexInc 1.1 (SD 2.4), WexCon 4.4 (SD 5.9). NBDS, WexCon and WexInc were significantly higher in PMS vs RRMS (p < 0.001), and significantly associated with disease duration, EDSS, multiple sclerosis severity score (p < 0.001), as well as with each other (p < 0.001). Our study confirms the presence of bowel dysfunctions in a large group of pwMS with a wide range of disability and their association with progressive disease phenotype and clinical disability.https://doi.org/10.1038/s41598-023-48317-9 |
| spellingShingle | Eleonora Tavazzi Antonio Zito Cristina Montomoli Niels Bergsland Elena Colombo Alessandro La Malfa Roberto Bergamaschi A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort Scientific Reports |
| title | A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort |
| title_full | A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort |
| title_fullStr | A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort |
| title_full_unstemmed | A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort |
| title_short | A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort |
| title_sort | multiscale assessment of bowel impairment in an italian multiple sclerosis cohort |
| url | https://doi.org/10.1038/s41598-023-48317-9 |
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