Treatment of phosphate retention: The earlier the better?
Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2014-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913213001149 |
| _version_ | 1818594537211166720 |
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| author | Patrick Biggar Samuel K.S. Fung Markus Ketteler |
| author_facet | Patrick Biggar Samuel K.S. Fung Markus Ketteler |
| author_sort | Patrick Biggar |
| collection | DOAJ |
| description | Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4. |
| first_indexed | 2024-12-16T11:01:42Z |
| format | Article |
| id | doaj.art-cd24802a46354c06a55f49cf860c3fc8 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-16T11:01:42Z |
| publishDate | 2014-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-cd24802a46354c06a55f49cf860c3fc82022-12-21T22:33:59ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322014-03-013313810.1016/j.krcp.2013.11.004Treatment of phosphate retention: The earlier the better?Patrick Biggar0Samuel K.S. Fung1Markus Ketteler2Klinikum Coburg GmbH, Department of Nephrology, Coburg, GermanyPrincess Margaret Hospital, Kowloon West Cluster Hospital Authority, Kowloon, Hong Kong SAR, ChinaKlinikum Coburg GmbH, Department of Nephrology, Coburg, GermanyOver the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4.http://www.sciencedirect.com/science/article/pii/S2211913213001149CalcificationChronic kidney diseaseFGF-23HyperphosphatemiaPhosphate bindersPrognosis |
| spellingShingle | Patrick Biggar Samuel K.S. Fung Markus Ketteler Treatment of phosphate retention: The earlier the better? Kidney Research and Clinical Practice Calcification Chronic kidney disease FGF-23 Hyperphosphatemia Phosphate binders Prognosis |
| title | Treatment of phosphate retention: The earlier the better? |
| title_full | Treatment of phosphate retention: The earlier the better? |
| title_fullStr | Treatment of phosphate retention: The earlier the better? |
| title_full_unstemmed | Treatment of phosphate retention: The earlier the better? |
| title_short | Treatment of phosphate retention: The earlier the better? |
| title_sort | treatment of phosphate retention the earlier the better |
| topic | Calcification Chronic kidney disease FGF-23 Hyperphosphatemia Phosphate binders Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2211913213001149 |
| work_keys_str_mv | AT patrickbiggar treatmentofphosphateretentiontheearlierthebetter AT samuelksfung treatmentofphosphateretentiontheearlierthebetter AT markusketteler treatmentofphosphateretentiontheearlierthebetter |