MiR-137 Targets the 3′ Untranslated Region of <i>MSH2</i>: Potential Implications in Lynch Syndrome-Related Colorectal Cancer

MiR-137 Targets the 3′ Untranslated Region of <i>MSH2</i>: Potential Implications in Lynch Syndrome-Related Colorectal Cancer

Mismatch Repair (<i>MMR</i>) gene dysregulation plays a fundamental role in Lynch Syndrome (LS) pathogenesis, a form of hereditary colorectal cancer. Loss or overexpression of key <i>MMR</i> genes leads to genome instability and tumorigenesis; however, the mechanisms controll...

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Bibliographic Details
Main Authors: Raffaella Liccardo, Raffaele Sessa, Silvia Trombetti, Marina De Rosa, Paola Izzo, Michela Grosso, Francesca Duraturo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
miR137
<i>MSH2</i>
Lynch Syndrome
regulation <i>MSH2</i> mRNA
3′UTR MSH2
<i>MMR</i> genes
Online Access:https://www.mdpi.com/2072-6694/13/18/4662

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