Influence of prostaglandin analogues on intraocular pressure fluctuations in body position change ABSTRACT
<p> <b>A.A. Antonov<sup>1</sup>, S.V. Vostrukhin<sup>2</sup>, A.V. Volzhanin<sup>1</sup>, A.A. Vitkov<sup>1</sup>, A.M. Akimov<sup>3</sup>, I.I. Asinovskova<sup>4</sup></b> </p> <p> <b><s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Prime-Media
2022-05-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/8fd/8fd4c936788813828afc566ff382693b.pdf |
| Summary: | <p>
<b>A.A. Antonov<sup>1</sup>, S.V. Vostrukhin<sup>2</sup>, A.V. Volzhanin<sup>1</sup>, A.A. Vitkov<sup>1</sup>, A.M. Akimov<sup>3</sup>, I.I. Asinovskova<sup>4</sup></b>
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<b><sup>1</sup> Scientific Research Institute of Eye Diseases, Moscow, Russian Federation</b>
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<b><sup>2</sup>JSC MedSef Ramenskoe, Ramenskoe, Russian Federation</b>
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<b><sup>3</sup> I.M. Sechenov First Moscow State Medical University (Sechenov University), <br>
Moscow, Russian Federation</b>
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<b><sup>4</sup>A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, <br>
Russian Federation</b>
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<i><b>Aim</b>: to assess the effects of prostaglandin F2α analogues on intraocular pressure (IOP) fluctuations when changing body position.</i>
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<i><b>Patients and Methods: </b>thirty-eight patients (50 eyes) with newly diagnosed primary open-angle glaucoma (POAG). Patients were examined before and one month after prescribing travoprost, a prostaglandin F2α analogue. During the examination, IOP was measured by Icare pro rebound tonometry and applanation tonometry (corneal-compensated IOP/ccIOP and Goldmann-correlated IOP/IOPg) in a sitting position. Next, IOP was measured by Icare tonometer twice with a 5-min interval in a supine position. Finally, IOP was measured by Icare tonometry and applanation tonometry (IOPcc, IOPg) in the sitting position.</i>
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<i><b>Results</b>: baseline IOPcc, IOPg, and IOP measured by Icare were 25.4±3.2 mm Hg, 25.7±2.3 mm Hg, and 22.9±3.4 mm Hg, respectively. IOP levels (Icare tonometry) in the supine position were 23.7±3.3 mm Hg and 24.0±3.3 mm Hg, respectively. In repeated measurements in the sitting position, IOPcc, IOPg, and IOP measured by Icare were 25.4±3.2 mm Hg, 25.7±2.4 mm Hg, and 22.3±3.4 mm Hg. One month after starting treatment with travoprost, IOPcc, IOPg, and IOP measured by Icare reduced to 18.2±2.7 mm Hg, 18.2±1.8 mm Hg, and 16.6±2.5 mm Hg, respectively. IOP levels (Icare tonometry) in the supine position were 17.3±2.8 mm Hg and 17.2±2.7 mm Hg, respectively. In repeated measurements in the sitting position, IOPcc, IOPg, and IOP measured by Icare were 18.0±2.3 mm Hg, 18.4±1.8 mm Hg, and 16.2±2.5 mm Hg, respectively. When transiting in a supine position, the differences in IOP levels were 0.83±1.04 mm Hg at baseline and 0.77±1.41 mm Hg after one month. When transiting in a sitting position, the differences in IOP levels were 1.66±1.24 mm Hg at baseline and 0.99±0. 98 mm Hg after one month.</i>
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<i><b>Conclusion</b>: travoprost as a starting monotherapy for POAG provides a long-lasting IOP reduction and minimizes its fluctuations when changing body position</i>
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<i><b>Keywords</b>: glaucoma, intraocular pressure, body position, rebound tonometry, prostaglandin analogue, travoprost.</i>
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<i><b>For citation:</b> Antonov A.A., Vostrukhin S.V., Volzhanin A.V. et al. Influence of prostaglandin analogues on intraocular pressure fluctuations in body position change. Russian Journal of Clinical Ophthalmology. 2022;22(2):103–107 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-103-107.</i>
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| ISSN: | 2311-7729 2619-1571 |