Development of a High Throughput Screen for the Identification of Inhibitors of Peptidoglycan <i>O-</i>Acetyltransferases, New Potential Antibacterial Targets

Development of a High Throughput Screen for the Identification of Inhibitors of Peptidoglycan <i>O-</i>Acetyltransferases, New Potential Antibacterial Targets

The <i>O</i>-acetylation of peptidoglycan occurs in many Gram-negative and most Gram-positive pathogens and this modification to the essential wall polymer controls the lytic activity of the autolysins, particularly the lytic transglycosylases, and inhibits that of the lysozymes of innat...

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Bibliographic Details
Main Authors: Ashley S. Brott, Carys S. Jones, Anthony J. Clarke
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Antibiotics
Subjects:
peptidoglycan
<i>O-</i>acetyltransferase
antibiotic target
high throughput screening
HTS
Online Access:https://www.mdpi.com/2079-6382/8/2/65

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