BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla
Object: To compare the BOLD fMRI signal characteristics in the cortex and on the pial surface for a non-balanced steady-state free precession sequence (nb-SSFP) at 7 T.<br/>Materials and methods: A multi-echo nb-SSFP sequence was used for high resolution fMRI at 7 T. Two S1 (S+) echoes at diff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00049/full |
| _version_ | 1828821894741098496 |
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| author | Pål Erik eGoa Pål Erik eGoa Pål Erik eGoa Peter Jan Koopmans Peter Jan Koopmans Peter Jan Koopmans Benedikt Andreas Poser Benedikt Andreas Poser Benedikt Andreas Poser Markus eBarth Markus eBarth David Gordon Norris David Gordon Norris David Gordon Norris |
| author_facet | Pål Erik eGoa Pål Erik eGoa Pål Erik eGoa Peter Jan Koopmans Peter Jan Koopmans Peter Jan Koopmans Benedikt Andreas Poser Benedikt Andreas Poser Benedikt Andreas Poser Markus eBarth Markus eBarth David Gordon Norris David Gordon Norris David Gordon Norris |
| author_sort | Pål Erik eGoa |
| collection | DOAJ |
| description | Object: To compare the BOLD fMRI signal characteristics in the cortex and on the pial surface for a non-balanced steady-state free precession sequence (nb-SSFP) at 7 T.<br/>Materials and methods: A multi-echo nb-SSFP sequence was used for high resolution fMRI at 7 T. Two S1 (S+) echoes at different echo times were acquired together with an S2 (S-) echo. The primary visual cortex (V1) was examined using a reversing checkerboard paradigm at an isotropic resolution of 0.75 mm, with 35 volumes acquired and a total scan time of 27 minutes.<br/>Results: Significant activation was observed in all subjects for all three acquired echoes. For the S1 signal at the longer TE, the activation induced signal change was about 4% in the cortex and 10 % at the cortical surface, while for S2 the corresponding values were 3% and 5%. <br/>Conclusion: For both S1 and S2 data, the BOLD signal peaks at the pial surface. The large pial surface signal change in S2 may be caused by dynamic averaging around post-capillary vessels embedded within CSF. This is made possible by the long diffusion times of the pathways contributing to the S2 signal and the relatively high diffusion coefficient of CSF. The results indicate that S2-SSFP might not be a suited alternative to spin-echo for high-resolution fMRI at 7 T. <br/> |
| first_indexed | 2024-12-12T13:03:25Z |
| format | Article |
| id | doaj.art-cd29358f37e94bb89378eb8ef828891f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T13:03:25Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-cd29358f37e94bb89378eb8ef828891f2022-12-22T00:23:43ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2014-03-01810.3389/fnins.2014.0004972503BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 TeslaPål Erik eGoa0Pål Erik eGoa1Pål Erik eGoa2Peter Jan Koopmans3Peter Jan Koopmans4Peter Jan Koopmans5Benedikt Andreas Poser6Benedikt Andreas Poser7Benedikt Andreas Poser8Markus eBarth9Markus eBarth10David Gordon Norris11David Gordon Norris12David Gordon Norris13MI-lab, Clinic of Radiology, St.Olavs Hospital HFErwin L. Hahn Institute of Magnetic Resonance Imaging, University Duisburg-EssenPresent Address: Department of Physics, Norwegian University of Science and TechnologyErwin L. Hahn Institute of Magnetic Resonance Imaging, University Duisburg-EssenRadboud University NijmegenPresent address FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of OxfordErwin L. Hahn Institute of Magnetic Resonance Imaging, University Duisburg-EssenRadboud University NijmegenPresent address Department of Cognitive Neuroscience, Maastricht Brain Imaging Centre (MBIC), Maastricht UniversityErwin L. Hahn Institute of Magnetic Resonance Imaging, University Duisburg-EssenRadboud University NijmegenErwin L. Hahn Institute of Magnetic Resonance Imaging, University Duisburg-EssenRadboud University NijmegenMIRA Institute for Biomedical Technology and Technical Medicine, University of TwenteObject: To compare the BOLD fMRI signal characteristics in the cortex and on the pial surface for a non-balanced steady-state free precession sequence (nb-SSFP) at 7 T.<br/>Materials and methods: A multi-echo nb-SSFP sequence was used for high resolution fMRI at 7 T. Two S1 (S+) echoes at different echo times were acquired together with an S2 (S-) echo. The primary visual cortex (V1) was examined using a reversing checkerboard paradigm at an isotropic resolution of 0.75 mm, with 35 volumes acquired and a total scan time of 27 minutes.<br/>Results: Significant activation was observed in all subjects for all three acquired echoes. For the S1 signal at the longer TE, the activation induced signal change was about 4% in the cortex and 10 % at the cortical surface, while for S2 the corresponding values were 3% and 5%. <br/>Conclusion: For both S1 and S2 data, the BOLD signal peaks at the pial surface. The large pial surface signal change in S2 may be caused by dynamic averaging around post-capillary vessels embedded within CSF. This is made possible by the long diffusion times of the pathways contributing to the S2 signal and the relatively high diffusion coefficient of CSF. The results indicate that S2-SSFP might not be a suited alternative to spin-echo for high-resolution fMRI at 7 T. <br/>http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00049/fullVisual CortexfMRIBOLD7Tsteady-state free precession |
| spellingShingle | Pål Erik eGoa Pål Erik eGoa Pål Erik eGoa Peter Jan Koopmans Peter Jan Koopmans Peter Jan Koopmans Benedikt Andreas Poser Benedikt Andreas Poser Benedikt Andreas Poser Markus eBarth Markus eBarth David Gordon Norris David Gordon Norris David Gordon Norris BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla Frontiers in Neuroscience Visual Cortex fMRI BOLD 7T steady-state free precession |
| title | BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla |
| title_full | BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla |
| title_fullStr | BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla |
| title_full_unstemmed | BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla |
| title_short | BOLD fMRI signal characteristics of S1- and S2-SSFP at 7 Tesla |
| title_sort | bold fmri signal characteristics of s1 and s2 ssfp at 7 tesla |
| topic | Visual Cortex fMRI BOLD 7T steady-state free precession |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00049/full |
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