Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial
Abstract Background We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012–2013 in the Netherlands. Postmenopausal overw...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-02-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12889-019-6510-1 |
| _version_ | 1828259220373372928 |
|---|---|
| author | Willemijn A. van Gemert Petra H. Peeters Anne M. May Adriaan J. H. Doornbos Sjoerd G. Elias Job van der Palen Wouter Veldhuis Maaike Stapper Jantine A. Schuit Evelyn M. Monninkhof |
| author_facet | Willemijn A. van Gemert Petra H. Peeters Anne M. May Adriaan J. H. Doornbos Sjoerd G. Elias Job van der Palen Wouter Veldhuis Maaike Stapper Jantine A. Schuit Evelyn M. Monninkhof |
| author_sort | Willemijn A. van Gemert |
| collection | DOAJ |
| description | Abstract Background We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012–2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6–7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (− 12.5% and − 12.0%) and exercise plus diet (− 16.0% and − 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm2 (95%CI -18.7; − 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (− 3.8 cm2, 95%CI -9.0; 1.3). Conclusions We conclude that weight loss of 6–7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register NCT01511276 (clinicaltrials.gov), prospectively registered. |
| first_indexed | 2024-04-13T03:04:34Z |
| format | Article |
| id | doaj.art-cd2afebc3c7f40d88144a4882e15ed13 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-13T03:04:34Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-cd2afebc3c7f40d88144a4882e15ed132022-12-22T03:05:18ZengBMCBMC Public Health1471-24582019-02-011911910.1186/s12889-019-6510-1Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trialWillemijn A. van Gemert0Petra H. Peeters1Anne M. May2Adriaan J. H. Doornbos3Sjoerd G. Elias4Job van der Palen5Wouter Veldhuis6Maaike Stapper7Jantine A. Schuit8Evelyn M. Monninkhof9Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtMedisch Spectrum Twente Hospital, Department of EpidemiologyDepartment of Radiology, University Medical Center UtrechtDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDivision of Public Health and Health Care, National Institute for Public Health and the EnvironmentDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtAbstract Background We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012–2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6–7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (− 12.5% and − 12.0%) and exercise plus diet (− 16.0% and − 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm2 (95%CI -18.7; − 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (− 3.8 cm2, 95%CI -9.0; 1.3). Conclusions We conclude that weight loss of 6–7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register NCT01511276 (clinicaltrials.gov), prospectively registered.http://link.springer.com/article/10.1186/s12889-019-6510-1Weight lossIntra-abdominal fatSubcutaneous fatExercise |
| spellingShingle | Willemijn A. van Gemert Petra H. Peeters Anne M. May Adriaan J. H. Doornbos Sjoerd G. Elias Job van der Palen Wouter Veldhuis Maaike Stapper Jantine A. Schuit Evelyn M. Monninkhof Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial BMC Public Health Weight loss Intra-abdominal fat Subcutaneous fat Exercise |
| title | Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial |
| title_full | Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial |
| title_fullStr | Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial |
| title_full_unstemmed | Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial |
| title_short | Effect of diet with or without exercise on abdominal fat in postmenopausal women – a randomised trial |
| title_sort | effect of diet with or without exercise on abdominal fat in postmenopausal women a randomised trial |
| topic | Weight loss Intra-abdominal fat Subcutaneous fat Exercise |
| url | http://link.springer.com/article/10.1186/s12889-019-6510-1 |
| work_keys_str_mv | AT willemijnavangemert effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT petrahpeeters effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT annemmay effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT adriaanjhdoornbos effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT sjoerdgelias effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT jobvanderpalen effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT wouterveldhuis effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT maaikestapper effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT jantineaschuit effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial AT evelynmmonninkhof effectofdietwithorwithoutexerciseonabdominalfatinpostmenopausalwomenarandomisedtrial |