mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like <i>Drosophila</i> Nephrocytes

mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like <i>Drosophila</i> Nephrocytes

Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases. However, the mechanistic role of these pathways for the glomerular filtration barrier remains poorly understood. We used <i>Drosophila<...

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Bibliographic Details
Main Authors: Dominik Spitz, Maria Comas, Lea Gerstner, Séverine Kayser, Martin Helmstädter, Gerd Walz, Tobias Hermle
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
nephrocyte
<i>Drosophila</i>
podocyte
mTOR
autophagy
slit diaphragm
Online Access:https://www.mdpi.com/2073-4409/11/13/2103

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