The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease
Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, and enterobacterial interactions are expected to provide a new target for the treatment of IBD. We collected recent studies on the enterobacterial interactions among the host, ent...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1188455/full |
| _version_ | 1797804488544747520 |
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| author | Siyu Li Siyu Li Kan Xu Kan Xu Yi Cheng Lu Chen Ailin Yi Zhifeng Xiao Xuefei Zhao Minjia Chen Yuting Tian Wei Meng Zongyuan Tang Shuhong Zhou Guangcong Ruan Yanling Wei |
| author_facet | Siyu Li Siyu Li Kan Xu Kan Xu Yi Cheng Lu Chen Ailin Yi Zhifeng Xiao Xuefei Zhao Minjia Chen Yuting Tian Wei Meng Zongyuan Tang Shuhong Zhou Guangcong Ruan Yanling Wei |
| author_sort | Siyu Li |
| collection | DOAJ |
| description | Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, and enterobacterial interactions are expected to provide a new target for the treatment of IBD. We collected recent studies on the enterobacterial interactions among the host, enterobacteria, and their metabolite products and discuss potential therapeutic options. Intestinal flora interactions in IBD are affected in the reduced bacterial diversity, impact the immune system and are influenced by multiple factors such as host genetics and diet. Enterobacterial metabolites such as SCFAs, bile acids, and tryptophan also play important roles in enterobacterial interactions, especially in the progression of IBD. Therapeutically, a wide range of sources of probiotics and prebiotics exhibit potential therapeutic benefit in IBD through enterobacterial interactions, and some have gained wide recognition as adjuvant drugs. Different dietary patterns and foods, especially functional foods, are novel therapeutic modalities that distinguish pro-and prebiotics from traditional medications. Combined studies with food science may significantly improve the therapeutic experience of patients with IBD. In this review, we provide a brief overview of the role of enterobacteria and their metabolites in enterobacterial interactions, discuss the advantages and disadvantages of the potential therapeutic options derived from such metabolites, and postulate directions for further research. |
| first_indexed | 2024-03-13T05:37:56Z |
| format | Article |
| id | doaj.art-cd2e56bc238b459eaf0f553bf610dc29 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T05:37:56Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-cd2e56bc238b459eaf0f553bf610dc292023-06-14T05:38:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.11884551188455The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel diseaseSiyu Li0Siyu Li1Kan Xu2Kan Xu3Yi Cheng4Lu Chen5Ailin Yi6Zhifeng Xiao7Xuefei Zhao8Minjia Chen9Yuting Tian10Wei Meng11Zongyuan Tang12Shuhong Zhou13Guangcong Ruan14Yanling Wei15Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaBasic Medicine College of Army Medical University, Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaBasic Medicine College of Army Medical University, Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Laboratory Animal Center, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, ChinaPharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to discontinue appropriately, and enterobacterial interactions are expected to provide a new target for the treatment of IBD. We collected recent studies on the enterobacterial interactions among the host, enterobacteria, and their metabolite products and discuss potential therapeutic options. Intestinal flora interactions in IBD are affected in the reduced bacterial diversity, impact the immune system and are influenced by multiple factors such as host genetics and diet. Enterobacterial metabolites such as SCFAs, bile acids, and tryptophan also play important roles in enterobacterial interactions, especially in the progression of IBD. Therapeutically, a wide range of sources of probiotics and prebiotics exhibit potential therapeutic benefit in IBD through enterobacterial interactions, and some have gained wide recognition as adjuvant drugs. Different dietary patterns and foods, especially functional foods, are novel therapeutic modalities that distinguish pro-and prebiotics from traditional medications. Combined studies with food science may significantly improve the therapeutic experience of patients with IBD. In this review, we provide a brief overview of the role of enterobacteria and their metabolites in enterobacterial interactions, discuss the advantages and disadvantages of the potential therapeutic options derived from such metabolites, and postulate directions for further research.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1188455/fullintestinal floraintestinal homeostasisinflammatory bowel diseaseshort chain fatty acids (SCFAs)functional foodsgut metabolome |
| spellingShingle | Siyu Li Siyu Li Kan Xu Kan Xu Yi Cheng Lu Chen Ailin Yi Zhifeng Xiao Xuefei Zhao Minjia Chen Yuting Tian Wei Meng Zongyuan Tang Shuhong Zhou Guangcong Ruan Yanling Wei The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease Frontiers in Microbiology intestinal flora intestinal homeostasis inflammatory bowel disease short chain fatty acids (SCFAs) functional foods gut metabolome |
| title | The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| title_full | The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| title_fullStr | The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| title_full_unstemmed | The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| title_short | The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| title_sort | role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease |
| topic | intestinal flora intestinal homeostasis inflammatory bowel disease short chain fatty acids (SCFAs) functional foods gut metabolome |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1188455/full |
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