Supporting a role for the GTPase Rab7 in prostate cancer progression.

Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive properties of Rab7, a GTPase that regulates trafficking of lysosomes. The movement of lysosomes to the cell surface in response to environme...

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Bibliographic Details
Main Authors: Joshua J Steffan, Samantha S Dykes, David T Coleman, Lisa K Adams, Donna Rogers, Jennifer L Carroll, B Jill Williams, James A Cardelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914878?pdf=render