BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. Metho...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221005981 |
| _version_ | 1819140072207810560 |
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| author | Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jeyadeepa Nandhini Selvaraj Dinesh Ashokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu |
| author_facet | Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jeyadeepa Nandhini Selvaraj Dinesh Ashokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu |
| author_sort | Nathella Pavan Kumar |
| collection | DOAJ |
| description | Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. Methods: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Results: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29. Conclusions: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses. |
| first_indexed | 2024-12-22T11:32:44Z |
| format | Article |
| id | doaj.art-cd353000be31426da076ee8aacbd3544 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-22T11:32:44Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-cd353000be31426da076ee8aacbd35442022-12-21T18:27:34ZengElsevierInternational Journal of Infectious Diseases1201-97122021-09-0111098104BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individualsNathella Pavan Kumar0Chandrasekaran Padmapriyadarsini1Anuradha Rajamanickam2Perumal Kannabiran Bhavani3Arul Nancy4Bharathi Jeyadeepa5Nandhini Selvaraj6Dinesh Ashokan7Rachel Mariam Renji8Vijayalakshmi Venkataramani9Srikanth Tripathy10Subash Babu11ICMR-National Institute for Research in Tuberculosis, Chennai, India; Corresponding authors: Nathella Pavan Kumar and Subash Babu, #1 Mayor Sathayamoorthy Road Chetpet, Chennai, 600031, India.ICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, IndiaICMR-National Institute for Research in Tuberculosis, Chennai, IndiaICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India; Corresponding authors: Nathella Pavan Kumar and Subash Babu, #1 Mayor Sathayamoorthy Road Chetpet, Chennai, 600031, India.Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. Methods: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Results: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29. Conclusions: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses.http://www.sciencedirect.com/science/article/pii/S1201971221005981BCGdendritic cellstype I and III interferonsCOVID-19 |
| spellingShingle | Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jeyadeepa Nandhini Selvaraj Dinesh Ashokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals International Journal of Infectious Diseases BCG dendritic cells type I and III interferons COVID-19 |
| title | BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals |
| title_full | BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals |
| title_fullStr | BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals |
| title_full_unstemmed | BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals |
| title_short | BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals |
| title_sort | bcg vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type i and type iii interferons in elderly individuals |
| topic | BCG dendritic cells type I and III interferons COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221005981 |
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