Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression

Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression

Abstract Norepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β2AR) on melanocyte stem cells (McSCs). From this, NA-β2AR axis could be a potential target for preventing the stress effect. However, identifying selective blockers for β2AR has been a...

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Bibliographic Details
Main Authors: Xinxin Li, Runlu Shi, Lingchen Yan, Weiwei Chu, Ruishuang Sun, Binkai Zheng, Shuai Wang, Hui Tan, Xusheng Wang, Ying Gao
Format: Article
Language:English
Published: SpringerOpen 2023-12-01
Series:Natural Products and Bioprospecting
Subjects:
Natural product
Rhynchophylline
Stress
Hair graying
β2 adrenergic signaling
Online Access:https://doi.org/10.1007/s13659-023-00421-z

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