The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

T lymphocyte cytotoxicity relies on a synaptic ring of lymphocyte function-associated antigen 1 (LFA-1), which permits polarized delivery of lytic granules. How LFA-1 organization is controlled by underlying actin cytoskeleton dynamics is poorly understood. Here, we explored the contribution of the...

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Bibliographic Details
Main Authors: Raïssa Houmadi, Delphine Guipouy, Javier Rey-Barroso, Zilton Vasconcelos, Julie Cornet, Manoel Manghi, Nicolas Destainville, Salvatore Valitutti, Sophie Allart, Loïc Dupré
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
Wiskott-Aldrich syndrome protein
cytotoxic T lymphocytes
immunological synapse
actin cytoskeleton
LFA-1
lytic granules
super-resolution microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319253

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