Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review
Context: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, atte...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2017-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-6-254.pdf |
| _version_ | 1797828003519004672 |
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| author | Saeid Heidari-Soreshjani Majid Asadi-Samani Qian Yang Ali Saeedi-Boroujeni |
| author_facet | Saeid Heidari-Soreshjani Majid Asadi-Samani Qian Yang Ali Saeedi-Boroujeni |
| author_sort | Saeid Heidari-Soreshjani |
| collection | DOAJ |
| description | Context: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. Results: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. Conclusions: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties. |
| first_indexed | 2024-04-09T12:57:30Z |
| format | Article |
| id | doaj.art-cd391bf12bb9474ca6cccf261568d199 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:30Z |
| publishDate | 2017-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-cd391bf12bb9474ca6cccf261568d1992023-05-13T11:31:23ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-07-016325426310.15171/jnp.2017.41jnp-20170517145531Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated reviewSaeid Heidari-Soreshjani0Majid Asadi-Samani1Qian Yang2Ali Saeedi-Boroujeni3Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranInstitute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, GermanyDepartment of Immunology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, IranContext: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. Results: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. Conclusions: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties.https://nephropathol.com/PDF/jnp-6-254.pdfnephrotoxicitycisplatincyclophosphamidechemotherapynatural compounds |
| spellingShingle | Saeid Heidari-Soreshjani Majid Asadi-Samani Qian Yang Ali Saeedi-Boroujeni Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review Journal of Nephropathology nephrotoxicity cisplatin cyclophosphamide chemotherapy natural compounds |
| title | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
| title_full | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
| title_fullStr | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
| title_full_unstemmed | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
| title_short | Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review |
| title_sort | phytotherapy of nephrotoxicity induced by cancer drugs an updated review |
| topic | nephrotoxicity cisplatin cyclophosphamide chemotherapy natural compounds |
| url | https://nephropathol.com/PDF/jnp-6-254.pdf |
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