A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics®
Anushree Seth, Dhirendra S KattiDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, IndiaAbstract: The influence of morphology and surface properties on the therapeutic efficacy of degradable polymeric microparticles has not been well u...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-09-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/a-one-step-electrospray-based-technique-for-modulating-morphology-and--a11118 |
| _version_ | 1818852151492870144 |
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| author | Seth A Katti DS |
| author_facet | Seth A Katti DS |
| author_sort | Seth A |
| collection | DOAJ |
| description | Anushree Seth, Dhirendra S KattiDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, IndiaAbstract: The influence of morphology and surface properties on the therapeutic efficacy of degradable polymeric microparticles has not been well understood. One of the primary reasons for this is the limited ability to fabricate microparticles with controlled morphology and surface properties. Here, we report the electrospraying of blends of Pluronic® with poly(lactide-co-glycolide) (PLGA) as a novel, one-step approach for the simultaneous modulation of morphology and surface properties of PLGA microparticles. Blending with Pluronic® altered the morphology from doughnut-shaped to smooth, spherical-shaped microparticles, and variation in the type of Pluronic® systematically modulated the surface properties of the microparticles. Hence, blending with Pluronic® can be a facile technique for the modulation of morphology and surface properties of electrosprayed PLGA microparticles.Keywords: blending, hydrophobicity, microstructures, surface charge, surface modification |
| first_indexed | 2024-12-19T07:16:22Z |
| format | Article |
| id | doaj.art-cd396475924e447781821cda9370ebba |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-19T07:16:22Z |
| publishDate | 2012-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-cd396475924e447781821cda9370ebba2022-12-21T20:31:04ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132012-09-012012default51295136A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics®Seth AKatti DSAnushree Seth, Dhirendra S KattiDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, IndiaAbstract: The influence of morphology and surface properties on the therapeutic efficacy of degradable polymeric microparticles has not been well understood. One of the primary reasons for this is the limited ability to fabricate microparticles with controlled morphology and surface properties. Here, we report the electrospraying of blends of Pluronic® with poly(lactide-co-glycolide) (PLGA) as a novel, one-step approach for the simultaneous modulation of morphology and surface properties of PLGA microparticles. Blending with Pluronic® altered the morphology from doughnut-shaped to smooth, spherical-shaped microparticles, and variation in the type of Pluronic® systematically modulated the surface properties of the microparticles. Hence, blending with Pluronic® can be a facile technique for the modulation of morphology and surface properties of electrosprayed PLGA microparticles.Keywords: blending, hydrophobicity, microstructures, surface charge, surface modificationhttp://www.dovepress.com/a-one-step-electrospray-based-technique-for-modulating-morphology-and--a11118 |
| spellingShingle | Seth A Katti DS A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® International Journal of Nanomedicine |
| title | A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® |
| title_full | A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® |
| title_fullStr | A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® |
| title_full_unstemmed | A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® |
| title_short | A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics® |
| title_sort | one step electrospray based technique for modulating morphology and surface properties of poly lactide co glycolide microparticles using pluronics amp reg |
| url | http://www.dovepress.com/a-one-step-electrospray-based-technique-for-modulating-morphology-and--a11118 |
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