A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides
ABSTRACT Epigenetic modifications might be associated with serum triglycerides (TG) levels. This study aims to systematically review the studies on the relationship between the methylation of specific cytosine-phosphate-guanine (CpG) sites and serum TG levels. This systematic review and meta-analysi...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2022-05-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300407&tlng=en |
| _version_ | 1818486682368868352 |
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| author | Sadegh Mazaheri-Tehrani Mehri Khoshhali Motahar Heidari-Beni Parnian Poursafa Roya Kelishadi |
| author_facet | Sadegh Mazaheri-Tehrani Mehri Khoshhali Motahar Heidari-Beni Parnian Poursafa Roya Kelishadi |
| author_sort | Sadegh Mazaheri-Tehrani |
| collection | DOAJ |
| description | ABSTRACT Epigenetic modifications might be associated with serum triglycerides (TG) levels. This study aims to systematically review the studies on the relationship between the methylation of specific cytosine-phosphate-guanine (CpG) sites and serum TG levels. This systematic review and meta-analysis study was conducted according to the PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. A systematic literature search was conducted in Medline database (PubMed), Scopus, and Cochrane library up to end of 2020. All observational studies (cross-sectional, case-control, and cohort) were included. Studies that assessed the effect of DNA methylation of different CpG sites of ABCG1, CPT1A, and SREBF1 genes on serum TG levels were selected. The National Institutes of Health (NIH) checklist was used to assess the quality of included articles. Among 2790 articles, ten studies were included in the quantitative analysis and fourteen studies were included in the systematic review. DNA methylation of ABCG1 gene had significant positive association with TG levels (β = 0.05, 95% CI = 0.04, 0.05, P heterogeneity < 0.001). There was significant inverse association between DNA methylation of CPT1A gene and serum TG levels (β = −0.03, 95% CI = −0.03, −0.02, P heterogeneity < 0.001). DNA methylation of SREBF1 gene was positively and significantly associated with serum TG levels (β = 0.03; 95% CI = 0.02-0.04, P heterogeneity < 0.001). DNA methylation of ABCG1 and SREBF1 genes has positive association with serum TG level, whereas this association is opposite for CPT1A gene. The role of epigenetic factors should be considered in some populations with high prevalence of hypertriglyceridemia. |
| first_indexed | 2024-12-10T16:26:22Z |
| format | Article |
| id | doaj.art-cd39648e3d934d518d09ee33f3814b75 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-10T16:26:22Z |
| publishDate | 2022-05-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-cd39648e3d934d518d09ee33f3814b752022-12-22T01:41:39ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-05-0166340741910.20945/2359-3997000000472A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglyceridesSadegh Mazaheri-Tehranihttps://orcid.org/0000-0002-7199-5696Mehri Khoshhalihttps://orcid.org/0000-0002-2883-8652Motahar Heidari-Benihttps://orcid.org/0000-0001-5543-5536Parnian Poursafahttps://orcid.org/0000-0001-7769-992XRoya Kelishadihttps://orcid.org/0000-0001-7455-1495ABSTRACT Epigenetic modifications might be associated with serum triglycerides (TG) levels. This study aims to systematically review the studies on the relationship between the methylation of specific cytosine-phosphate-guanine (CpG) sites and serum TG levels. This systematic review and meta-analysis study was conducted according to the PRISMA 2020 (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. A systematic literature search was conducted in Medline database (PubMed), Scopus, and Cochrane library up to end of 2020. All observational studies (cross-sectional, case-control, and cohort) were included. Studies that assessed the effect of DNA methylation of different CpG sites of ABCG1, CPT1A, and SREBF1 genes on serum TG levels were selected. The National Institutes of Health (NIH) checklist was used to assess the quality of included articles. Among 2790 articles, ten studies were included in the quantitative analysis and fourteen studies were included in the systematic review. DNA methylation of ABCG1 gene had significant positive association with TG levels (β = 0.05, 95% CI = 0.04, 0.05, P heterogeneity < 0.001). There was significant inverse association between DNA methylation of CPT1A gene and serum TG levels (β = −0.03, 95% CI = −0.03, −0.02, P heterogeneity < 0.001). DNA methylation of SREBF1 gene was positively and significantly associated with serum TG levels (β = 0.03; 95% CI = 0.02-0.04, P heterogeneity < 0.001). DNA methylation of ABCG1 and SREBF1 genes has positive association with serum TG level, whereas this association is opposite for CPT1A gene. The role of epigenetic factors should be considered in some populations with high prevalence of hypertriglyceridemia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300407&tlng=enTriglyceridesepigenomicsDNA methylationmeta-analysis |
| spellingShingle | Sadegh Mazaheri-Tehrani Mehri Khoshhali Motahar Heidari-Beni Parnian Poursafa Roya Kelishadi A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides Archives of Endocrinology and Metabolism Triglycerides epigenomics DNA methylation meta-analysis |
| title | A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| title_full | A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| title_fullStr | A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| title_full_unstemmed | A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| title_short | A systematic review and meta-analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| title_sort | systematic review and meta analysis of observational studies on the effects of epigenetic factors on serum triglycerides |
| topic | Triglycerides epigenomics DNA methylation meta-analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300407&tlng=en |
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