A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
Abstract Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging as a preferred tool since it enables...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05531-5 |
| _version_ | 1797557170089230336 |
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| author | Eliana Steinberg Roy Friedman Yoel Goldstein Nethanel Friedman Ofer Beharier Jonathan Abraham Demma Gideon Zamir Ayala Hubert Ofra Benny |
| author_facet | Eliana Steinberg Roy Friedman Yoel Goldstein Nethanel Friedman Ofer Beharier Jonathan Abraham Demma Gideon Zamir Ayala Hubert Ofra Benny |
| author_sort | Eliana Steinberg |
| collection | DOAJ |
| description | Abstract Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging as a preferred tool since it enables the complex set-ups and recapitulation of the physiologically relevant physical microenvironment of tumors. In order to overcome the common hindrances encountered while using this technology, a fully 3D-printed device was developed that sustains patient-derived multicellular spheroids long enough to conduct multiple drug screening tests. This tool is both cost effective and possesses four necessary characteristics of effective microfluidic devices: transparency, biocompatibility, versatility, and sample accessibility. Compelling correlations which demonstrate a clinical proof of concept were found after testing and comparing different chemotherapies on tumor spheroids, derived from ten patients, to their clinical outcomes. This platform offers a potential solution for personalized medicine by functioning as a predictive drug-performance tool. |
| first_indexed | 2024-03-10T17:13:33Z |
| format | Article |
| id | doaj.art-cd3a26afe6e04fd694fb6f94dc25b78a |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:13:33Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-cd3a26afe6e04fd694fb6f94dc25b78a2023-11-20T10:35:10ZengNature PortfolioCommunications Biology2399-36422023-11-016111410.1038/s42003-023-05531-5A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicineEliana Steinberg0Roy Friedman1Yoel Goldstein2Nethanel Friedman3Ofer Beharier4Jonathan Abraham Demma5Gideon Zamir6Ayala Hubert7Ofra Benny8The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of JerusalemSchool of Computer Science and Engineering, Center for Interdisciplinary Data Research, The Hebrew University of JerusalemThe Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of JerusalemThe Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of JerusalemHadassah Medical Center and The Hebrew University of JerusalemDepartment of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of JerusalemDepartment of General Surgery, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of JerusalemOncology Department, Hadassah Medical CenterThe Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of JerusalemAbstract Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging as a preferred tool since it enables the complex set-ups and recapitulation of the physiologically relevant physical microenvironment of tumors. In order to overcome the common hindrances encountered while using this technology, a fully 3D-printed device was developed that sustains patient-derived multicellular spheroids long enough to conduct multiple drug screening tests. This tool is both cost effective and possesses four necessary characteristics of effective microfluidic devices: transparency, biocompatibility, versatility, and sample accessibility. Compelling correlations which demonstrate a clinical proof of concept were found after testing and comparing different chemotherapies on tumor spheroids, derived from ten patients, to their clinical outcomes. This platform offers a potential solution for personalized medicine by functioning as a predictive drug-performance tool.https://doi.org/10.1038/s42003-023-05531-5 |
| spellingShingle | Eliana Steinberg Roy Friedman Yoel Goldstein Nethanel Friedman Ofer Beharier Jonathan Abraham Demma Gideon Zamir Ayala Hubert Ofra Benny A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine Communications Biology |
| title | A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine |
| title_full | A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine |
| title_fullStr | A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine |
| title_full_unstemmed | A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine |
| title_short | A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine |
| title_sort | fully 3d printed versatile tumor on a chip allows multi drug screening and correlation with clinical outcomes for personalized medicine |
| url | https://doi.org/10.1038/s42003-023-05531-5 |
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