Influence of Specific Leptospirosis Prevention to Epidemic Process
Aim of the study was to investigate the features of vaccine prevention of leptospirosis and its influence on morbidity.Materials and methods. The incidence of human leptospirosis in the Russian Federation in 1956–2016, 41 cases of disease in Siberia and the Far East in 2012–2016, official Rossel...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2019-03-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/669 |
| _version_ | 1797879620430725120 |
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| author | N. V. Breneva V. M. Korzun I. V. Meltsov A. A. Umanets D. Yu. Cusin Yu. S. Musatov Т. V. Gromova А. V. Allenov |
| author_facet | N. V. Breneva V. M. Korzun I. V. Meltsov A. A. Umanets D. Yu. Cusin Yu. S. Musatov Т. V. Gromova А. V. Allenov |
| author_sort | N. V. Breneva |
| collection | DOAJ |
| description | Aim of the study was to investigate the features of vaccine prevention of leptospirosis and its influence on morbidity.Materials and methods. The incidence of human leptospirosis in the Russian Federation in 1956–2016, 41 cases of disease in Siberia and the Far East in 2012–2016, official Rossel'khoznadzor data, volumes of laboratory studies and vaccination of animals in Primorsk Territory and Irkutsk Region were analyzed. Blood sera from 7315 humans, 2189 dogs, 481 bovine animals and 50 small cattle, 115 pigs, 88 horses were investigated to pathogenic Leptospira antibodies.Results. Essential significance of vaccinal leptospiroses prevention in farm animals and dogs to decrease the epizootic and epidemic process activities is demonstrated. Currently, the epidemic process in Siberia and at the Far East includes only sporadic cases, the immune stratum of the population is 3,7 ± 0,2%. Postvaccinal antibody titres in dogs, pigs and small cattle rarely exceed 1:100 while in bovine animals and horses it can reach 1:800 without disease signs.Conclusion. Human immunization in the antropurgic foci is impractical at effective specific prophylaxis for animals. The standard base for leptospiroses requires improvement. The concept of absolute and relative diagnostic antibody titer in microagglutination test is offered to use in clinical diagnostics. In veterinary the correction of diagnostic titer depending on the animal species and vaccination time is necessary. |
| first_indexed | 2024-04-10T02:50:22Z |
| format | Article |
| id | doaj.art-cd3b91a9c3d7458493eb57a5e240dd83 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:50:22Z |
| publishDate | 2019-03-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-cd3b91a9c3d7458493eb57a5e240dd832023-03-13T07:43:16ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942019-03-01181889510.31631/2073-3046-2019-88-95512Influence of Specific Leptospirosis Prevention to Epidemic ProcessN. V. Breneva0V. M. Korzun1I. V. Meltsov2A. A. Umanets3D. Yu. Cusin4Yu. S. Musatov5Т. V. Gromova6А. V. Allenov7ФКУЗ «Иркутский научно-исследовательский противочумный институт» Роспотребнадзора, г. ИркутскФКУЗ «Иркутский научно-исследовательский противочумный институт» Роспотребнадзора, г. ИркутскСлужба ветеринарии Иркутской области, г. ИркутскГосударственная ветеринарная инспекция Приморского края, г. ВладивостокГосударственная ветеринарная инспекция Приморского края, г. ВладивостокФКУЗ «Хабаровская противочумная станция» Роспотребнадзора, г. ХабаровскФКУЗ «Хабаровская противочумная станция» Роспотребнадзора, г. ХабаровскФКУЗ «Приморская противочумная станция» Роспотребнадзора, г. УссурийскAim of the study was to investigate the features of vaccine prevention of leptospirosis and its influence on morbidity.Materials and methods. The incidence of human leptospirosis in the Russian Federation in 1956–2016, 41 cases of disease in Siberia and the Far East in 2012–2016, official Rossel'khoznadzor data, volumes of laboratory studies and vaccination of animals in Primorsk Territory and Irkutsk Region were analyzed. Blood sera from 7315 humans, 2189 dogs, 481 bovine animals and 50 small cattle, 115 pigs, 88 horses were investigated to pathogenic Leptospira antibodies.Results. Essential significance of vaccinal leptospiroses prevention in farm animals and dogs to decrease the epizootic and epidemic process activities is demonstrated. Currently, the epidemic process in Siberia and at the Far East includes only sporadic cases, the immune stratum of the population is 3,7 ± 0,2%. Postvaccinal antibody titres in dogs, pigs and small cattle rarely exceed 1:100 while in bovine animals and horses it can reach 1:800 without disease signs.Conclusion. Human immunization in the antropurgic foci is impractical at effective specific prophylaxis for animals. The standard base for leptospiroses requires improvement. The concept of absolute and relative diagnostic antibody titer in microagglutination test is offered to use in clinical diagnostics. In veterinary the correction of diagnostic titer depending on the animal species and vaccination time is necessary.https://www.epidemvac.ru/jour/article/view/669лептоспирозвакцинацияэпидемический процессэпизоотическая ситуация |
| spellingShingle | N. V. Breneva V. M. Korzun I. V. Meltsov A. A. Umanets D. Yu. Cusin Yu. S. Musatov Т. V. Gromova А. V. Allenov Influence of Specific Leptospirosis Prevention to Epidemic Process Эпидемиология и вакцинопрофилактика лептоспироз вакцинация эпидемический процесс эпизоотическая ситуация |
| title | Influence of Specific Leptospirosis Prevention to Epidemic Process |
| title_full | Influence of Specific Leptospirosis Prevention to Epidemic Process |
| title_fullStr | Influence of Specific Leptospirosis Prevention to Epidemic Process |
| title_full_unstemmed | Influence of Specific Leptospirosis Prevention to Epidemic Process |
| title_short | Influence of Specific Leptospirosis Prevention to Epidemic Process |
| title_sort | influence of specific leptospirosis prevention to epidemic process |
| topic | лептоспироз вакцинация эпидемический процесс эпизоотическая ситуация |
| url | https://www.epidemvac.ru/jour/article/view/669 |
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