ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
During last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mecha...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/49 |
| _version_ | 1797198186521034752 |
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| author | O. .A. Gankovskaya |
| author_facet | O. .A. Gankovskaya |
| author_sort | O. .A. Gankovskaya |
| collection | DOAJ |
| description | During last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mechanisms with genetic factors in pregnant women were poorly studied. The aim of present study was to evaluate associations between the following SNPs: Arg677Trp, Arg753Gln of TLR2 gene, A2848G SNP of TLR9 gene, and frequencies of pre-term birth complicated by infections in Russian population of Moscow City. SNPs Arg677Trp, Arg753Gln in TLR2 gene have been studied in a clinical material by means of PCR-RFLP analysis, using AciI restrictase. A2848G polymorphic marker in TLR9 gene was assessed by real-time PCR, employing TaqMan probes. It has been shown, that Arg allele of Arg753Gln TLR2 gene was associated with urogenital infections. When studying A2848G polymorphism in TLR9 gene, the A Allele was associated with normal delivery, thus assuming the A2848G polymorphic marker as a protective one. |
| first_indexed | 2024-03-08T05:51:58Z |
| format | Article |
| id | doaj.art-cd3c554a483b47848fc27adc86ceb445 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:51Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-cd3c554a483b47848fc27adc86ceb4452024-04-22T13:07:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01121-2879410.15789/1563-0625-2010-1-2-48ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONSO. .A. Gankovskaya0ГУ НИИ вакцин и сывороток им. И.И. Мечникова РАМН, Москва ГОУ ВПО РГМУ Росздрава, МоскваDuring last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mechanisms with genetic factors in pregnant women were poorly studied. The aim of present study was to evaluate associations between the following SNPs: Arg677Trp, Arg753Gln of TLR2 gene, A2848G SNP of TLR9 gene, and frequencies of pre-term birth complicated by infections in Russian population of Moscow City. SNPs Arg677Trp, Arg753Gln in TLR2 gene have been studied in a clinical material by means of PCR-RFLP analysis, using AciI restrictase. A2848G polymorphic marker in TLR9 gene was assessed by real-time PCR, employing TaqMan probes. It has been shown, that Arg allele of Arg753Gln TLR2 gene was associated with urogenital infections. When studying A2848G polymorphism in TLR9 gene, the A Allele was associated with normal delivery, thus assuming the A2848G polymorphic marker as a protective one.https://www.mimmun.ru/mimmun/article/view/49inborn immunitytoll-like receptorspolimorphismpretermbirthurogenital infeсtion |
| spellingShingle | O. .A. Gankovskaya ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS Медицинская иммунология inborn immunity toll-like receptors polimorphism pretermbirth urogenital infeсtion |
| title | ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS |
| title_full | ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS |
| title_fullStr | ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS |
| title_full_unstemmed | ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS |
| title_short | ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS |
| title_sort | association studies between polymorphic markers tlr2 and tlr9 pre term delivery and intrauterine infections |
| topic | inborn immunity toll-like receptors polimorphism pretermbirth urogenital infeсtion |
| url | https://www.mimmun.ru/mimmun/article/view/49 |
| work_keys_str_mv | AT oagankovskaya associationstudiesbetweenpolymorphicmarkerstlr2andtlr9pretermdeliveryandintrauterineinfections |