The binding and mechanism of a positive allosteric modulator of Kv3 channels
Abstract Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal approach to elucidate the mechanism of action of an...
Main Authors: | Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin J. Gunthorpe, Giuseppe Alvaro, Charles H. Large, David B. Sauer, Werner Treptow, Manuel Covarrubias |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-46813-8 |
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